Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Jaundice

Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.


Total: 22

                      


(per page)
PMID (PMCID)
30254770
(6142722)
OTHER
Biliary Obstruction due to a Pancreatic Plasmacytoma.
Cho MH, Mandaliya R, Tran J, Lee W, Patel M.
Case Rep Gastrointest Med. 2018;2018:9017617.
Herein, we describe a case of multiple myeloma presenting as a pancreatic plasmacytoma causing obstructive jaundice.
26166129
(4504588)
MALE
The Detection of Pancreatic and Retroperitoneal Plasmacytoma Helped to Diagnose Multiple Myeloma: A Case Report.
Utsumi T, Sasajima J, Goto T, Fujibayashi S, Dokoshi T, Sakatani A, Tanaka K, Nomura Y, Ueno N, Kashima S, Inaba Y, Inamura J, Shindo M, Moriichi K, Fujiya M, Kohgo Y.
Medicine (Baltimore). 2015;94(27):e914.
We herein report a rare case of pancreatic plasmacytoma, which was detected before the diagnosis of multiple myeloma.An 83-year-old male was referred to our hospital for further evaluation of obstructive jaundice and a pancreatic mass.
26345572
MALE Middle Aged
[Relapsed/refractory multiple myeloma with CD138 shedding and formation of extramedullary disease in the common bile duct region presenting as obstructive jaundice].
Yokoyama A, Hosoda T, Shiraishi J, Yamamoto R, Yoneda M, Ohashi K, Okabe T, Kagoo T, Boku S, Ueno H, Yano T.
Rinsho Ketsueki. 2015;56(8):1089-95.
[Relapsed/refractory multiple myeloma with CD138 shedding and formation of extramedullary disease in the common bile duct region presenting as obstructive jaundice].
22993370
MALE
Lenalidomide-associated hepatotoxicity--a case report and literature review.
Nojkov B, Signori C, Konda A, Fontana RJ.
Anticancer Res. 2012;32(9):4117-9.
A 67-year-old male with multiple myeloma was hospitalized with nausea, vomiting and jaundice, while treated with a second three-week course of lenalidomide.
22466837
MALE
Liver failure caused by light chain deposition disease associated with multiple myeloma.
Mena-Duran A, Munoz Vicente E, Pareja Llorens G, Sanchis Cervera J.
Intern Med. 2012;51(7):773-6.
Here, we report a case of multiple myeloma with light chain deposition disease (LCDD) that presented with progressive jaundice due to intrahepatic cholestasis.
21060710
(2975009)
OTHER
Pancreatic and Gastric Plasmacytoma Presenting with Obstructive Jaundice, Diagnosed with Endoscopic Ultrasound-Guided Fine Needle Aspiration.
Padda MS, Milless T, Adeniran AJ, Mahooti S, Aslanian HR.
Case Rep Gastroenterol. 2010;4(3):410-415.
A 75-year-old male with a known history of multiple myeloma presented with obstructive jaundice and a pancreatic mass.
19404208
MALE
Jaundice revealing a k light chain myeloma because of liver light chain deposits.
Montialoux H, Savoye G, Savoye-Collet C, Ramirez S, Francois A, Lerebours E, Goria O.
Eur J Gastroenterol Hepatol. 2009;21(7):827-9.
We report the case of a 77-year-old man referred for jaundice and diagnosed with intrahepatic light chain deposit as primary manifestation of a kappa light chain multiple myeloma.
19295251
FEMALE Adult
Relapse of IgA lambda multiple myeloma presenting as obstructive jaundice and abdominal pain.
Annibali O, Marchesi F, Petrucci MT, Tirindelli MC, Avvisati G.
Onkologie. 2009;32(3):119-21.
Relapse of IgA lambda multiple myeloma presenting as obstructive jaundice and abdominal pain.
19265303
MALE
[Hepatic hilus extramedullary plasmacytoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy in a relapsed multiple myeloma].
Oyama N, Ise M, Mimura N, Tsujimura H, Sakai C, Kumagai K.
Rinsho Ketsueki. 2009;50(2):102-6.
We report a rare case of multiple myeloma that developed extramedullary plasmacytoma at the hilus of the liver causing obstructive jaundice.
15481613
(4531562)
MALE Middle Aged
Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report.
Bang SM, Kim SS, Park SH, Ahn JY, Cho EK, Shin DB, Lee JH.
Korean J Intern Med. 2004;19(3):196-8.
After 5-months' administration of thalidomide for the second relapse of the multiple myeloma, he suddenly experienced dizziness and jaundice.
15299163
MALE
IgA multiple myeloma presenting as non-obstructive jaundice.
Arebi N, Patel B, Aqel NM, Pitcher MC.
Postgrad Med J. 2004;80(946):489-90.
Multiple myeloma can occasionally present with jaundice.
15299163
MALE
IgA multiple myeloma presenting as non-obstructive jaundice.
Arebi N, Patel B, Aqel NM, Pitcher MC.
Postgrad Med J. 2004;80(946):489-90.
IgA multiple myeloma presenting as non-obstructive jaundice.
11991600
MALE Adult
Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome.
Michopoulos S, Petraki K, Petraki C, Dimopoulos MA.
Dig Dis Sci. 2002;47(4):730-4.
We describe a 36-year-old man with advanced multiple myeloma (Salmon and Durie stage III) who developed jaundice and severe cholestasis after a first cure with systemic chemotherapy of vincristine, doxorubicin, and oral dexamethasone (VAD).
9662276
MALE Adult
Solitary extramedullary plasmacytoma in the retroperitoneum.
Chen TC, Wu JH, Ng KF, Lien JM, Hung CF.
Am J Hematol. 1998;58(3):235-8.
Therefore, the possibility of a solitary extramedullary plasmacytoma should be considered in the differential diagnosis of obstructive jaundice without a history of multiple myeloma.
7647907
FEMALE
Hepatic failure in a case of multiple myeloma-associated amyloidosis (kappa-AL)
Yamamoto T, Maeda N, Kawasaki H.
J Gastroenterol. 1995;30(3):393-7.
At the time that the diagnosis of IgG-kappa type multiple myeloma was made, jaundice was advanced, with continuous gastrointestinal bleeding.
8193237
FEMALE
[Jaundice secondary to intrahepatic deposit of light chains as a presenting form of multiple myeloma].
Macias Robles MD, Navia-Osorio Garcia-Braga JM, Menendez Caro JL, Velasco Alonso J, Lopez Lagunas I.
An Med Interna. 1994;11(2):74-6.
Bearing this in mind, we present the clinical and evolutive characteristics of a patient diagnosed of IgG Kappa multiple myeloma, whose first manifestation was a jaundice syndrome with intrahepatic deposit of light chains documented in the anatomopathologic study and in which, despite presenting renal failure, deposits of light chains were not observed in the renal biopsy.
2179601
MALE Middle Aged
[Multiple myeloma causing obstructive jaundice by extramedullary plasmacytoma after Bence Jones protein loss--an autopsy case report].
Hamamoto K, Kosaka C, Takeno M, Anzai N, Tezuka H, Konishi H, Yagiri Y, Ueda Y.
Rinsho Ketsueki. 1990;31(1):57-61.
[Multiple myeloma causing obstructive jaundice by extramedullary plasmacytoma after Bence Jones protein loss--an autopsy case report].
2179601
MALE Middle Aged
[Multiple myeloma causing obstructive jaundice by extramedullary plasmacytoma after Bence Jones protein loss--an autopsy case report].
Hamamoto K, Kosaka C, Takeno M, Anzai N, Tezuka H, Konishi H, Yagiri Y, Ueda Y.
Rinsho Ketsueki. 1990;31(1):57-61.
It was a rare case of multiple myeloma in which pleural effusion and multiple plasmacytomas, and finally obstructive jaundice were developed although urinary BJP (kappa) was reduced by treatment.
3539507
MALE Middle Aged
Obstructive jaundice secondary to multiple myeloma--a case report.
Zafaranloo S, Bryk D, Gerard PS.
Comput Radiol. 1986;10(4):197-200.
Reported is a patient who presented with clinical obstructive jaundice caused by multiple myeloma involving the pancreatic head.
3539507
MALE Middle Aged
Obstructive jaundice secondary to multiple myeloma--a case report.
Zafaranloo S, Bryk D, Gerard PS.
Comput Radiol. 1986;10(4):197-200.
Obstructive jaundice secondary to multiple myeloma--a case report.