Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Purpura

Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This term refers to an abnormally increased susceptibility to developing purpura. Purpura are larger than petechiae.


Total: 15

                       


(per page)
PMID (PMCID)
24851244
 FEMALE Middle Aged
Resident rounds: Part III: Multiple myeloma presenting as fulminant retiform purpura.
Hoesly FJ, Sluzevich JC.
J Drugs Dermatol. 2014;13(4):498.
Retiform purpura secondary to underlying type 1 cryoglobulinemia can be a presenting sign of multiple myeloma.
24851244
 FEMALE Middle Aged
Resident rounds: Part III: Multiple myeloma presenting as fulminant retiform purpura.
Hoesly FJ, Sluzevich JC.
J Drugs Dermatol. 2014;13(4):498.
Resident rounds: Part III: Multiple myeloma presenting as fulminant retiform purpura.
21729687
 FEMALE Middle Aged
Paraneoplastic cutaneous leukocytoclastic vasculitis disclosing multiple myeloma: a case report.
Peterlin P, Ponge T, Blin N, Moreau P, Hamidou M, Agard C.
Clin Lymphoma Myeloma Leuk. 2011;11(4):373-4.
Purpura resolved after specific treatment of multiple myeloma and diagnosis of paraneoplastic purpura was asserted.
21729687
 FEMALE Middle Aged
Paraneoplastic cutaneous leukocytoclastic vasculitis disclosing multiple myeloma: a case report.
Peterlin P, Ponge T, Blin N, Moreau P, Hamidou M, Agard C.
Clin Lymphoma Myeloma Leuk. 2011;11(4):373-4.
Purpura resolved after specific treatment of multiple myeloma and diagnosis of paraneoplastic purpura was asserted.
21729687
 FEMALE Middle Aged
Paraneoplastic cutaneous leukocytoclastic vasculitis disclosing multiple myeloma: a case report.
Peterlin P, Ponge T, Blin N, Moreau P, Hamidou M, Agard C.
Clin Lymphoma Myeloma Leuk. 2011;11(4):373-4.
We report the case of an uncommon presentation of an IgA lambda multiple myeloma in a 58 year-old woman preceded by vascular purpura with cutaneous leukocytoclastic vasculitis (LV) and intense deposit of IgA and kappa light chains in the dermal vessels.
16731392
 FEMALE Middle Aged
Bullous amyloidosis of the oral cavity: a rare clinical presentation and review.
Stoopler ET, Alawi F, Laudenbach JM, Sollecito TP.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(6):734-40.
Hemorrhagic bullae indicative of BA are usually associated with purpura and may be the initial clinical signs of systemic amyloidosis or monoclonal gammopathies, such as multiple myeloma and Waldenstrom's macroglobulinemia.
15164605
 FEMALE
[A novel molecular marker for thrombus formation and life prognosis--clinical usefulness of measurement of soluble fibrin monomer-fibrinogen complex (SF)].
Koga S.
Rinsho Byori. 2004;52(4):355-61.
Underlying disease includes leukemias, malignant lymphoma, myelodysplastic syndrome (MDS), multiple myeloma, idiopathic thrombocytopenia purpura(ITP), multiple injury (bone fracture), cerebral hemorrhage, enterocolitis, Appendicitis, lung cancer, larynx cancer, bronchiolitis obliterans organizing pneumonia(BOOP), chronic obstructive pulmonary disease(COPD), sepsis.
12956761
 MALE Middle Aged
Immunoglobulin A multiple myeloma presenting with Henoch-Schonlein purpura associated with reduced sialylation of IgA1.
Van Der Helm-Van Mil AH, Smith AC, Pouria S, Tarelli E, Brunskill NJ, Eikenboom HC.
Br J Haematol. 2003;122(6):915-7.
IgA multiple myeloma, secreting IgA1 molecules with decreased sialylation, presenting with a Henoch-Schonlein purpura-like syndrome was diagnosed.
12956761
 MALE Middle Aged
Immunoglobulin A multiple myeloma presenting with Henoch-Schonlein purpura associated with reduced sialylation of IgA1.
Van Der Helm-Van Mil AH, Smith AC, Pouria S, Tarelli E, Brunskill NJ, Eikenboom HC.
Br J Haematol. 2003;122(6):915-7.
Immunoglobulin A multiple myeloma presenting with Henoch-Schonlein purpura associated with reduced sialylation of IgA1.
11347514
 MALE Adult
[Severe Henoch-Schonlein purpura in a patient with multiple myeloma].
Conte G, Conte FJ, Ojeda JM, Araos D, Poniachik J, Murray G, Flores C.
Rev Med Chil. 2000;128(11):1255-60.
[Severe Henoch-Schonlein purpura in a patient with multiple myeloma].
8630124
 MALE Middle Aged
IgA multiple myeloma presenting as Henoch-Schonlein purpura/polyarteritis nodosa overlap syndrome.
Birchmore D, Sweeney C, Choudhury D, Konwinski MF, Carnevale K, D'Agati V.
Arthritis Rheum. 1996;39(4):698-703.
We report the unusual case of a man with a 5-year history of relapsing Henoch-Schonlein purpura (HSP) and macroscopic polyarteritis nodosa (PAN) as early manifestations of IgA kappa multiple myeloma.
8630124
 MALE Middle Aged
IgA multiple myeloma presenting as Henoch-Schonlein purpura/polyarteritis nodosa overlap syndrome.
Birchmore D, Sweeney C, Choudhury D, Konwinski MF, Carnevale K, D'Agati V.
Arthritis Rheum. 1996;39(4):698-703.
IgA multiple myeloma presenting as Henoch-Schonlein purpura/polyarteritis nodosa overlap syndrome.
2456509
 FEMALE Adult
New and controversial uses of intravenous gamma-globulin.
Pahwa RN.
Pediatr Infect Dis J. 1988;7(5 Suppl):S34-6.
myasthenia gravis, systemic lupus erythematosus, idiopathic thrombocytopenic purpura, idiopathic neutropenia and aplastic anemia; (3) atopic allergy with IgG subclass deficiency including bronchial asthma; (4) in severe infections in combination therapy with antibiotics and as an antipyretic; (5) in Kawasaki's disease; (6) in multiple myeloma and chronic lymphocytic leukemia.
7012198
 MALE
Bullous amyloidosis.
Beacham BE, Greer KE, Andrews BS, Cooper PH.
J Am Acad Dermatol. 1980;3(5):506-10.
The variety of cutaneous lesions in primary systemic or multiple myeloma-associated amyloidosis is impressive and includes purpura, waxy papules, tumors, plaques, alopecia, and, rarely, bullae.
6782799
 MALE
Hyperglobulinemic purpura in the course of multiple myeloma.
Shalit M, Bar-Sela S, Leviatan A, Naparstek Y.
Acta Haematol. 1980;64(6):331-4.
Hyperglobulinemic purpura in the course of multiple myeloma.