Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Polyneuropathy

A generalized disorder of peripheral nerves.


Total: 24

                       


(per page)
PMID (PMCID)
28775105
 MALE
POEMS syndrome in a patient with rheumatoid arthritis.
Akagi T, Mukai T, Kodama S, Morita Y.
BMJ Case Rep. 2017;2017:.
POEMS syndrome is a rare variant of multiple myeloma and is characterised by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes.
26513367
 FEMALE Middle Aged
Amyloidosis of the Breast: Three Different and Unusual Presentations of a Rare Entity.
Herrero L, Naranjo-Hans D, Sole M, Santamaria G, Bargallo X, Velasco M, Fernandez PL.
Pathobiology. 2015;82(6):264-8.
Together with a case presenting in a patient with multiple myeloma, we describe 2 unique presentations including 1 associated with CREST syndrome in a patient with a previous history of breast carcinoma and another, also associated with cancer, with transthyretin deposits in a woman with a TTR gene mutation and a family history of familial amyloidotic polyneuropathy.
25992284
 OTHER
Severe reversible pulmonary hypertension in smoldering multiple myeloma: two cases and review of the literature.
Feyereisn WL, Fenstad ER, McCully RB, Lacy MQ.
Pulm Circ. 2015;5(1):211-6.
An association between pulmonary hypertension (PH) and POEMS syndrome (characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) as well as other plasma cell dyscrasias, including multiple myeloma (MM), has been shown to exist.
24139142
(4016595)
 OTHER
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma and skin changes) with cranial vault plasmocytoma and the role of surgery in its management: a case report.
Plata Bello J, Garcia-Marin V.
J Med Case Rep. 2013;7:245.
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma and skin changes) with cranial vault plasmocytoma and the role of surgery in its management: a case report.
24139142
(4016595)
 OTHER
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma and skin changes) with cranial vault plasmocytoma and the role of surgery in its management: a case report.
Plata Bello J, Garcia-Marin V.
J Med Case Rep. 2013;7:245.
POEMS syndrome (an acronym of polyneuropathy, organomegaly, endocrinopathy, multiple myeloma and skin changes) is a paraneoplastic disorder related to an underlying plasma cell dyscrasia.
20031303
 MALE Middle Aged
Intracranial plasmacytoma with apoplectic presentation and spontaneous intracerebral hemorrhage: Case report and review of the literature.
Crowley RW, Sansur CA, Sheehan JP, Mandell JW, Kassell NF, Dumont AS.
Clin Neurol Neurosurg. 2010;112(2):172-5.
Involvement of the nervous system is not uncommon in patients with multiple myeloma, with polyneuropathy and myelopathy predominating.
17080761
 MALE
[Blue discoloration of hands, numbness of feet, indolent cervical lymph node swelling in a 73-year-old man].
Kurzen C, Kunz I, Nigg C.
Praxis (Bern 1994). 2006;95(41):1589-93.
So all the criterias for a POEMS syndrome (special form of multiple myeloma) were met with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes.
11587522
 MALE Middle Aged
Solitary osteosclerotic plasmacytoma: association with demyelinating polyneuropathy and amyloid deposition.
Voss SD, Murphey MD, Hall FM.
Skeletal Radiol. 2001;30(9):527-9.
These lesions are less likely to progress to multiple myeloma than lytic plasma cell neoplasms, and the presence of polyneuropathy often results in earlier diagnosis and treatment with enhanced prospect of cure.
10339780
 MALE Middle Aged
Polyradiculoneuropathy revealing a solitary plasmacytoma of the ilium. A new case-report.
Niamane R, Benomar A, Messouak W, Benabdejlil M, Benabdellah C, Yahyaoui M, Hajjaj-Hassouni N, Chkili T.
Rev Rhum Engl Ed. 1999;66(4):229-31.
Subacute or chronic polyradiculoneuropathy as the inaugural manifestation of solitary plasmacytoma is exceedingly rare and should be distinguished from the sensorimotor polyneuropathy produced by plasma cell infiltration in some multiple myeloma patients.
9631362
 FEMALE
Multiple myeloma with associated polyneuropathy in a German shepherd dog.
Villiers E, Dobson J.
J Small Anim Pract. 1998;39(5):249-51.
Multiple myeloma with associated polyneuropathy in a German shepherd dog.
10074579
 MALE Adult
POEMS syndrome, steroid-dependent diabetes mellitus, erythema elevatum diutinum, and rheumatoid arthritis as extramedullary manifestations of plasma cell dyscrasia.
Albitar S, Bourgeon B, Genin R, Jacquesson M, Riviere JP, Serveaux MO, Ribera A, Serveaux JP.
Am J Kidney Dis. 1998;31(4):E3.
However, prednisone and plasmapheresis had no effect on polyneuropathy, M-paraprotein, and plasma cell dyscrasia in our patient, who developed indolent multiple myeloma a few years later.
2185597
 MALE Adult
Syndrome of plasma cell dyscrasia, polyneuropathy, and diabetes mellitus.
Davies ML, Elson DL, Hertz D, McMillin JM.
West J Med. 1990;152(3):257-60.
Multiple myeloma associated with sclerotic bone lesions and polyneuropathy represents a distinct subset of the plasma cell dyscrasias.
2848651
 FEMALE Middle Aged
Heavy- and free light-chain myeloma associated with peripheral polyneuropathy.
Cotariu D, Kaufman S, Golik A, Scharf S, Zaidman JL.
Clin Chem. 1988;34(12):2594-5.
Here we describe a case of multiple myeloma and polyneuropathy with both monoclonal IgG and free lambda light chains in the blood.
2848651
 FEMALE Middle Aged
Heavy- and free light-chain myeloma associated with peripheral polyneuropathy.
Cotariu D, Kaufman S, Golik A, Scharf S, Zaidman JL.
Clin Chem. 1988;34(12):2594-5.
Peripheral polyneuropathy, a rare complication of multiple myeloma, is generally associated with heavy-chain M-proteins and, in very rare instances, with free light-chain myeloma proteins.
3083799
 MALE Middle Aged
Multiple myeloma with polyneuropathy and coagulopathy. A case report of the polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin change (POEMS) syndrome.
Hyman BT, Westrick MA.
Arch Intern Med. 1986;146(5):993-4.
A patient with the syndrome of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) had multiple myeloma and IgA-kappa monoclonal gammopathy.
3083799
 MALE Middle Aged
Multiple myeloma with polyneuropathy and coagulopathy. A case report of the polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin change (POEMS) syndrome.
Hyman BT, Westrick MA.
Arch Intern Med. 1986;146(5):993-4.
Multiple myeloma with polyneuropathy and coagulopathy.
2939079
 MIXED_SAMPLE Adult
Plasma cell sclerosis of bone: a spectrum of disease.
Sartoris DJ, Pate D, Haghighi P, Greenway G, Resnick D.
Can Assoc Radiol J. 1986;37(1):25-34.
These conditions include multiple myeloma, plasma cell granuloma, sternocostoclavicular hyperostosis, the POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes), and chronic symmetric plasma cell osteomyelitis of childhood.
6096963
 MIXED_SAMPLE Adult
[Neurologic manifestations of monoclonal gammapathies].
Uldry PA, Steck AJ, Regli F.
Schweiz Med Wochenschr. 1984;114(47):1678-85.
We have studied 8 patients with monoclonal gammopathy (2 "monoclonal gammopathies of undetermined significance" [MGUS], 2 multiple myeloma and 4 Waldenstrom's macroglobulinemia) and associated neurological complications (polyneuropathy, encephalopathy, noncompressive myelopathy).
6784440
 FEMALE Middle Aged
Sensorimotor polyneuropathy in light chain multiple myeloma.
Pellegrini G, Scarlato G, Moggio M, Bettinelli C, Gaini SM.
Acta Neuropathol Suppl. 1981;7:255-7.
Sensorimotor polyneuropathy in light chain multiple myeloma.
6253777
 FEMALE Middle Aged
Multiple myeloma with bilateral orbital infiltration and polyneuropathy.
Hayes JG, Petersen M, Kakulas BA.
Med J Aust. 1980;2(5):276-7.
Multiple myeloma with bilateral orbital infiltration and polyneuropathy.