Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.


Total: 147

                       


(per page)
PMID (PMCID)
30984433
 OTHER
Bone Marrow Aspirate Clot: A Useful Technique in Diagnosis and Follow-Up of Hematological Disorders.
Cantadori LO, Gaiolla RD, Niero-Melo L, Oliveira CC.
Case Rep Hematol. 2019;2019:7590948.
Here, we highlight the utility of the bone marrow aspirate clot, exemplifying through the discussion of three clinical cases in which this technique was used for diagnosis and follow-up purposes: megaloblastic hemopathy, multiple myeloma, and chronic lymphocytic leukemia.
30671213
 OTHER
Bortezomib Maintenance for the Treatment of Monoclonal Gammopathy of Renal Significance.
Lee H, Duggan P, Neri P, Tay J, Jimenez-Zepeda VH.
Mediterr J Hematol Infect Dis. 2019;11(1):e2019007.
Monoclonal gammopathy of renal significance (MGRS) defines renal diseases resulting from the nephrotoxic effects of monoclonal proteins secreted from non-malignant clonal B cells or plasma cells, that do not meet criteria for multiple myeloma, Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia, or lymphomas.
30033442
(6066981)
 MALE
Acquired Hemophilia of Unknown Etiology in an Elderly Man: Case Report.
Stephen SE, Loong JLX, Hoong CK, Lim SM, Botross NP.
Am J Case Rep. 2018;19:858-863.
In approximately 10% of patients with acquired hemophilia, underlying malignancy, such as squamous cell cancer, chronic lymphocytic leukemia, non-Hodgkin lymphoma, and multiple myeloma can present and commonly develop in elderly patients.
29046749
(5637643)
 OTHER
An unusual case of chronic lymphocytic leukemia, multiple myeloma and cardiac amyloidosis.
Liu D, Uqdah HT, Gordy AD.
J Community Hosp Intern Med Perspect. 2017;7(4):230-233.
An unusual case of chronic lymphocytic leukemia, multiple myeloma and cardiac amyloidosis.
29046749
(5637643)
 OTHER
An unusual case of chronic lymphocytic leukemia, multiple myeloma and cardiac amyloidosis.
Liu D, Uqdah HT, Gordy AD.
J Community Hosp Intern Med Perspect. 2017;7(4):230-233.
We reported on a 76-years-old female who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted multiple myeloma with plasma cells causing AL amyloidosis involving the heart.
29390389
(5815801)
 FEMALE
Treatment-related acute granulocyte-monocytic leukemia from multiple myeloma: A case report and literature review.
Qian J, Shi W, Yang L, Lin Z, Cai Y, Liu H.
Medicine (Baltimore). 2017;96(50):e9293.
To investigate the clinical features of treatment-related acute granulocyte-monocytic leukemia (t-AML) from multiple myeloma (MM) thereby improving the understanding of this disease.
29390389
(5815801)
 FEMALE
Treatment-related acute granulocyte-monocytic leukemia from multiple myeloma: A case report and literature review.
Qian J, Shi W, Yang L, Lin Z, Cai Y, Liu H.
Medicine (Baltimore). 2017;96(50):e9293.
Treatment-related acute granulocyte-monocytic leukemia from multiple myeloma: A case report and literature review.
27408384
 OTHER
Concomitant Presence of Two Distinct Clones of Chronic Lymphocytic Leukemia and Plasma Cell Myeloma in a Patient.
Langer S, Mehta M, Saraf A, Gupta A, Pipliya K, Kakar A, Bhargava M.
Indian J Hematol Blood Transfus. 2016;32(Suppl 1):173-7.
Concomitant Presence of Two Distinct Clones of Chronic Lymphocytic Leukemia and Plasma Cell Myeloma in a Patient.
27408384
 OTHER
Concomitant Presence of Two Distinct Clones of Chronic Lymphocytic Leukemia and Plasma Cell Myeloma in a Patient.
Langer S, Mehta M, Saraf A, Gupta A, Pipliya K, Kakar A, Bhargava M.
Indian J Hematol Blood Transfus. 2016;32(Suppl 1):173-7.
The final diagnosis of chronic lymphocytic leukemia with concomittant presence of plasma cell myeloma was concluded.
26782803
 FEMALE
Critical Pitfalls in the use of BRAF Mutation as a Diagnostic Tool in Thyroid Nodules: a Case Report.
Kuhn E, Ragazzi M, Zini M, Giordano D, Nicoli D, Piana S.
Endocr Pathol. 2016;27(3):220-3.
Notably, BRAF (V600E) mutation is common in melanoma, colorectal carcinoma, lung carcinoma, ovarian carcinoma, brain tumors, hairy cell leukemia, multiple myeloma, and histiocytoses.
27446359
(4950900)
 OTHER
Secondary lymphoblastic leukemia occurring 38 months after the primary diagnosis of multiple myeloma: A case report.
Li J, Zhan J, Zhang F, Ye Z, Ouyang J.
Oncol Lett. 2016;12(2):847-856.
Secondary lymphoblastic leukemia occurring 38 months after the primary diagnosis of multiple myeloma: A case report.
26166219
 FEMALE Adult
Three patients with multiple myeloma developing secondary lymphoblastic leukemia: case reports and review of the literature.
Junxun L, Junru L, Meilan C, Chujia L, Shaoqian C, Jieyu Z, Zhuangjian Y, Fan Z, Juan O, Jing C, Juan L.
Tumori. 2016;102(Suppl. 2):.
We report 3 cases of secondary lymphoblastic leukemia in multiple myeloma patients.
27795764
(5072883)
 MIXED_SAMPLE Middle Aged
[Primary plasma cell leukemia: about 3 cases].
Miloudi M, Messaoudi N.
Pan Afr Med J. 2016;24:167.
It may be primary in 60% of cases and it manifests itself immediately as a leukemia or as a secondary event, in 40% of cases, complicating a previously diagnosed multiple myeloma.
26394545
 MIXED_SAMPLE Middle Aged
Could ehrlichial infection cause some of the changes associated with leukemia, myelodysplastic diseases and autoimmune disorders, and offer antibiotic treatment options?
Kallick CA, Friedman DA, Nyindo MB.
Med Hypotheses. 2015;85(6):891-3.
We hypothesize that a large group of medical conditions of unknown etiology including leukemia, multiple myeloma, myelodysplastic and autoimmune disorders, may be associated with or caused by an obscure group of intracellular obligate parasitic bacteria named Ehrlichia/Anaplasma (EA).
26622719
 OTHER
Nuclear medicine techniques in Merkel cell carcinoma: A case report and review of the literature.
Kritikos N, Priftakis D, Stavrinides S, Kleanthous S, Sarafianou E.
Oncol Lett. 2015;10(3):1610-1616.
Risk factors include immune-suppressing diseases, such as human immunodeficiency virus (HIV), chronic lymphocytic leukemia and multiple myeloma, organ transplantation, and the presence of the newly-identified Merkel cell polyomavirus (MCPyV).
24426351
 OTHER
A Rare Case of Hemoglobin E Hemoglobinopathy with Gaucher's Disease.
Chatterjee T, Dewan K, Ganguli P, Das S, Sharma A, Sahni AK, Nath P.
Indian J Hematol Blood Transfus. 2013;29(2):110-2.
Presence of Gaucher-like cells with normal 946-glucocerebrosidase (pseudo-Gaucher cells) are known in leukemia, multiple myeloma, thalassemia and mycobacterial infections.
23801131
 FEMALE
Simultaneous presentation of Waldenstrom macroglobulinemia and multiple myeloma: multidisciplinary diagnosis, treatment and 30-month follow-up.
Carulli G, Ciancia EM, Azzara A, Ottaviano V, Grassi S, Ciabatti E, Ferreri MI, Rocco M, Marini A, Petrini M.
J Clin Exp Hematop. 2013;53(1):29-36.
Multiple myeloma has been described in association with other indolent B-cell neoplasms, mostly chronic lymphocytic leukemia, while Waldenstrom macroglobulinemia can be followed by diffuse large B-cell lymphoma in some instances, after chemotherapy.
22404949
 MALE Middle Aged
Concomitant Waldenstrom macroglobulinemia and IgA plasmablastic myeloma in a patient with untreated IgM paraproteinemia: sequential development of biclonal B-cell neoplasms over a 10-year period in a single individual.
Wang E, Kulbacki E, Stoecker M.
Hum Pathol. 2012;43(7):1135-41.
Plasma cell myeloma has been described in association with other indolent B-cell lymphomas, particularly chronic lymphocytic leukemia, but concomitant Waldenstrom macroglobulinemia and plasma cell myeloma has not been previously described.
22404949
 MALE Middle Aged
Concomitant Waldenstrom macroglobulinemia and IgA plasmablastic myeloma in a patient with untreated IgM paraproteinemia: sequential development of biclonal B-cell neoplasms over a 10-year period in a single individual.
Wang E, Kulbacki E, Stoecker M.
Hum Pathol. 2012;43(7):1135-41.
Plasma cell myeloma has been described in association with other indolent B-cell lymphomas, particularly chronic lymphocytic leukemia, but concomitant Waldenstrom macroglobulinemia and plasma cell myeloma has not been previously described.
22662644
 MALE Adult
Sarcoidosis and multiple sclerosis: systemic toxicity associated with the use of interferon-beta therapy.
Carbonelli C, Montepietra S, Caruso A, Cavazza A, Feo C, Menzella F, Motti L, Zucchi L.
Monaldi Arch Chest Dis. 2012;77(1):29-31.
Interferons are immuno-modulators that have been used in a wide range of diseases, including hepatitis C virus infection, multiple sclerosis, and multiple myeloma and other types of tumours, including leukemia, lymphomas, Kaposi's sarcoma, and melanoma.