Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Acute leukemia

A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).


Total: 20

                       


(per page)
PMID (PMCID)
25838910
(4377252)
 OTHER
Fulminant onset of acute leukemia from normal hematopoiesis within 3months of follow up for multiple myeloma treated with total therapy protocols.
Singh ZN, Jethava Y, Post GR, Alapat D, Sawyer J, Waheed S, Nair B, Usmani SZ, Bailey C, Petty N, Van Rhee F, Barlogie B.
Clin Case Rep. 2015;3(3):183-92.
Fulminant onset of acute leukemia from normal hematopoiesis within 3months of follow up for multiple myeloma treated with total therapy protocols.
12874768
 MALE
Plasmablastic transformation of multiple myeloma.
Lee CK, Ma ES, Shek TW, Lam CC, Au WY, Wan TS, Chan LC.
Hum Pathol. 2003;34(7):710-4.
We describe morphological, immunophenotypic, and cytogenetic characterization of a case of multiple myeloma (MM) that showed plasmablastic transformation at the terminal phase with a picture resembling acute leukemia.
14567751
 MALE
Simultaneous presentation of multiple myeloma and acute monocytic leukemia.
Luca DC, Almanaseer IY.
Arch Pathol Lab Med. 2003;127(11):1506-8.
Acute leukemia frequently has been described as a late complication of chemotherapy with alkylating agents in patients treated for multiple myeloma.
14567751
 MALE
Simultaneous presentation of multiple myeloma and acute monocytic leukemia.
Luca DC, Almanaseer IY.
Arch Pathol Lab Med. 2003;127(11):1506-8.
However, the simultaneous occurrence of multiple myeloma and acute leukemia in the same patient, without previous exposure to chemotherapy, is a rare association.
7563597
 FEMALE
[Secondary myeloid/natural killer cell acute leukemia appeared in multiple myeloma treated with melphalan].
Kaya H, Nakamura S, Yamazaki H, Kumabashiri I, Ohtake S, Matsuda T.
Rinsho Ketsueki. 1995;36(7):682-6.
We diagnosed as multiple myeloma complicated with secondary myeloid/natural killer (NK) cell acute leukemia.
7563597
 FEMALE
[Secondary myeloid/natural killer cell acute leukemia appeared in multiple myeloma treated with melphalan].
Kaya H, Nakamura S, Yamazaki H, Kumabashiri I, Ohtake S, Matsuda T.
Rinsho Ketsueki. 1995;36(7):682-6.
This case was interesting one in coexist of multiple myeloma and secondary myeloid/NK cell acute leukemia, and those affecting her clinical course each other.
7563597
 FEMALE
[Secondary myeloid/natural killer cell acute leukemia appeared in multiple myeloma treated with melphalan].
Kaya H, Nakamura S, Yamazaki H, Kumabashiri I, Ohtake S, Matsuda T.
Rinsho Ketsueki. 1995;36(7):682-6.
[Secondary myeloid/natural killer cell acute leukemia appeared in multiple myeloma treated with melphalan].
1942522
 MIXED_SAMPLE Adult
[Clinical investigation on acute respiratory failure in patients with severe hematologic malignancy].
Hino K, Iguchi K, Sato S, Kawakami K, Ueno H, Akimoto Y, Nakamaki T, Ishiyama T, Suzuki K, Tomoyasu S, et al..
Rinsho Ketsueki. 1991;32(8):831-7.
Ten patients with severe hematologic malignancies (four with acute leukemia, three with multiple myeloma, one with prolymphocytic leukemia, one with malignant lymphoma and one with blastic crisis of chronic myelogenous leukemia) developed respiratory failure during the period between April 1986 and May 1990.
2363415
 FEMALE Middle Aged
Acute leukemia evolving from multiple myeloma and co-expressing myeloid and plasma cell antigens.
Stewart AK, Freedman J, Garvey MB.
Am J Hematol. 1990;34(3):210-4.
Acute leukemia evolving from multiple myeloma and co-expressing myeloid and plasma cell antigens.
6582056
 MIXED_SAMPLE Adult
Acute surgical abdomen caused by thrombocytopenia in patients with acute leukemia and multiple myeloma.
Kornberg A, Eldor A.
Isr J Med Sci. 1983;19(12):1094-6.
Acute surgical abdomen caused by thrombocytopenia in patients with acute leukemia and multiple myeloma.
6582056
 MIXED_SAMPLE Adult
Acute surgical abdomen caused by thrombocytopenia in patients with acute leukemia and multiple myeloma.
Kornberg A, Eldor A.
Isr J Med Sci. 1983;19(12):1094-6.
One patient with multiple myeloma and four patients with acute leukemia presented with severe abdominal pain.
7080865
 MIXED_SAMPLE Middle Aged
Melphalan-related leukemia in multiple myeloma.
Wahlin A, Roos G, Rudolphi O, Holm J.
Acta Med Scand. 1982;211(3):203-8.
Five patients with multiple myeloma ending in acute leukemia are described.
6781197
 MALE
Multiple myeloma and acute myelomonocytic leukemia: simultaneous occurrence without previous chemotherapy.
Annino L, Martino P, Barsotti P, Serra P, Marinozzi V, Mandelli F.
Acta Haematol. 1980;64(4):195-200.
A possible relationship between acute leukemia and multiple myeloma is discussed.
119404
 MALE
Multiple myeloma and acute leukemia.
Kastanas GA, Papaioannou CA, Nathena HA.
Acta Haematol. 1979;62(2):78-80.
A patient suffering from multiple myeloma without treatment with cytoxic drugs or irradiation, died within 4 months, from acute leukemia.
119404
 MALE
Multiple myeloma and acute leukemia.
Kastanas GA, Papaioannou CA, Nathena HA.
Acta Haematol. 1979;62(2):78-80.
The appearance of acute leukemia in a patient with multiple myeloma without previous treatment is very unusual.
385972
 MIXED_SAMPLE Middle Aged
[Acute leukemia in multiple myeloma: case histories, a review of the literature and assessment of the incidence].
Bierbach H, Zeile G, Wellek S, Fischer J.
Klin Wochenschr. 1979;57(15):769-77.
[Acute leukemia in multiple myeloma: case histories, a review of the literature and assessment of the incidence].
214859
 MIXED_SAMPLE Middle Aged
[Multiple myeloma and acute leukemia. Simultaneous evolution of plasmacyte and myelomonocytic clones].
Renoux M, Bernard JF, Bezeau A, Amar M, Boivin P.
Sem Hop. 1978;54(25-28):809-13.
[Multiple myeloma and acute leukemia.
1064744
 MALE Adult
Clinically significant cardiac infiltration in acute leukemia, lymphocytic lymphoma, and plasma cell myeloma.
Wiernik PH, Sutherland JC, Stechmiller BK, Wolff J.
Med Pediatr Oncol. 1976;2(1):75-85.
Clinically significant cardiac infiltration in acute leukemia, lymphocytic lymphoma, and plasma cell myeloma.
1063053
 MIXED_SAMPLE Adult
Multiple myeloma, acute leukemia, and Hodgkin's disease. Occurrence in three of four family members.
Kyle RA, Henderson ES, Randolph VL, Budge WR.
Cancer. 1976;37(3):1496-99.
No increased incidence of deaths attributed to Hodgkin's disease, acute leukemia, or multiple myeloma was found in the community.
1063053
 MIXED_SAMPLE Adult
Multiple myeloma, acute leukemia, and Hodgkin's disease. Occurrence in three of four family members.
Kyle RA, Henderson ES, Randolph VL, Budge WR.
Cancer. 1976;37(3):1496-99.
Multiple myeloma, acute leukemia, and Hodgkin's disease.