Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Osteolysis

Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium.


Total: 12

                       


(per page)
PMID (PMCID)
28875143
(5583203)
 OTHER
A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report.
Viviano M, Addamo A, Cocca S.
J Korean Assoc Oral Maxillofac Surg. 2017;43(4):272-275.
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia.
25813262
 MALE
[A rare case of multiple myeloma: multiple solitary plasmacytomas of distal extremities].
Hrabovsky , ehak Z, Stulik J, Praek J, Mayer J.
Vnitr Lek. 2015;61(2):161-5.
This article describes a case of 68-years-old male with very atypic variation of multiple myeloma occuring as multifocal osteolysis limited to tibiae, cuboid bone, radius and ulna, in the absence of diffuse bone marrow infiltration.
24021907
 MALE
Approach to diagnosis and treatment of hypercalcemia in a patient with malignancy.
Reagan P, Pani A, Rosner MH.
Am J Kidney Dis. 2014;63(1):141-7.
There are 4 broad mechanistic categories to classify hypercalcemia of malignancy: local osteolysis secondary to metastatic cancer or multiple myeloma, excess parathyroid-related hormone, excess 1,25-dihydroxyvitamin D production, and ectopic parathyroid hormone production.
24326882
 MALE
[Multiple myeloma with significant multifocal osteolysis in a dog without a detectible gammopathy].
Souchon F, Koch A, Sohns A.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2013;41(6):413-20.
[Multiple myeloma with significant multifocal osteolysis in a dog without a detectible gammopathy].
19012489
 MALE
Multiple myeloma manifesting as an intraventricular brain tumor.
Eum JH, Jeibmann A, Wiesmann W, Paulus W, Ebel H.
J Neurosurg. 2009;110(4):737-9.
After postoperative radio- and chemotherapy, vertebral osteolysis was detected as a secondary manifestation of multiple myeloma.
18068658
 MALE
Jaw avascular osteonecrosis after treatment of multiple myeloma with zoledronate.
Lobato JV, Mauricio AC, Rodrigues JM, Cavaleiro MV, Cortez PP, Xavier L, Botelho C, Hussain NS, Santos JD.
J Plast Reconstr Aesthet Surg. 2008;61(1):99-106.
The major clinical manifestation of multiple myeloma is related to the loss of bone through osteolysis.
17868526
 MIXED_SAMPLE Adult
Maxilla osseus sequestre and oral exposure: effects of the treatment of multiple myeloma with bisphosphonates.
Lobato JV, Rodrigues JM, Cavaleiro MV, Lobato JM, Xavier L, Santos JD, Mauricio AC.
Acta Med Port. 2007;20(2):185-92.
The major clinical manifestation of multiple myeloma is related to loss of bone through osteolysis.
17918494
 MALE
[Multiple myeloma as a cause of rapid acetabular osteolysis].
Akiki A, Arlettaz Y.
Rev Med Suisse. 2007;3(123):1968-70.
[Multiple myeloma as a cause of rapid acetabular osteolysis].
17918494
 MALE
[Multiple myeloma as a cause of rapid acetabular osteolysis].
Akiki A, Arlettaz Y.
Rev Med Suisse. 2007;3(123):1968-70.
The wear and shear particles of polyethylene or metal are the leading cause of reactive osteolysis in total hip arthroplasty, nevertheless multiple myeloma or metastatic lesions should be included in the differentail diagnosis.
8212953
 MIXED_SAMPLE
Bone lesions of multiple myeloma in three dogs.
Maeda H, Ozaki K, Abe T, Matsui H, Sano M, Narama I.
Zentralbl Veterinarmed A. 1993;40(5):384-92.
Osteolytic lesions did not necessarily involve tumor growth, explaining the inconsistent confirmation of tumor cells in biopsy specimens for diagnosis of multiple myeloma and suggesting the possible mechanism for osteolysis by some other humoral factors.
863778
 FEMALE
Idiopathic monoclonal (IgA) gammopathy in a dog.
Dewhirst MW, Stamp GL, Hurvitz AI.
J Am Vet Med Assoc. 1977;170(11):1313-6.
Idiopathic monoclonal (IgA) gammopathy in a dog was differentiated from multiple myeloma, based on the lack of Bence Jones proteinuria, no osteolysis, and no plasma cell infiltration into bone marrow, as well as on the stability of the gammopathy for over 18 months.
826383
 MALE Adult
[Alpha-chain disease presenting as malabsorption syndrome with exudative enteropathy (author's transl)].
Roth S, Havemann K, Kalbfleisch H, Menge H, Riecken EO, Sodomann CP, Martini GA.
Dtsch Med Wochenschr. 1976;101(50):1823-8.
Skeletal X-rays showed no osteolysis and the bone marrow showed no evidence for multiple myeloma.