Constriction rings syndrome

Constriction rings syndrome is a congenital limb malformation disorder with an extremely variable clinical presentation characterized by the presence of partial to complete, congenital, fibrous, circumferential, constriction bands/rings on any part of the body, although a particular predilection for the upper or lower extremities is seen. Phenotypes range from only a mild skin indentation to complete amputation of parts of the fetus (e.g. digits, distal limb). Compression from the rings may lead to edema, skeletal anomalies (e.g. fractures, foot deformities) and, infrequently, neural compromise.

Vascular dilatation

Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart.

Total: 1

(per page)

PMID (PMCID)
10327252	FEMALE	Adult
	Terminal transverse limb defects with tethering and omphalocele in a 17 week fetus following first trimester misoprostol exposure.
	Genest DR, Di Salvo D, Rosenblatt MJ, Holmes LB. Clin Dysmorphol. 1999;8(1):53-8.
	The association in this case of the phenotypic features of the amniotic band syndrome suggests that the teratogenicity of misoprostol at 9 to 12 weeks gestation can overlap that of other acute insults at that time, such as chorionic villus sampling, dilatation and curettage and abdominal trauma in the first trimester.