Tangier disease

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.

Diabetes mellitus

A group of abnormalities characterized by hyperglycemia and glucose intolerance.


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PMID (PMCID)
3019588
 MALE Adult
Erythrocyte membrane alterations and plasma lipids in patients with chylomicronemia and in Tangier disease.
Frohlich J, Godin DV.
Clin Biochem. 1986;19(4):229-34.
The relationship between erythrocyte membrane structural and functional alterations and plasma lipids was studied in three patients with chylomicronemia due to either lipoprotein lipase (LPL) deficiency, apo C-II deficiency (in an individual who also suffers from thalassemia minor) or coexistent diabetes mellitus (and decreased LPL activity) and in a patient with Tangier disease.