Tangier disease

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.

Facial diplegia

Facial diplegia refers to bilateral facial palsy (bilateral facial palsy is much rarer than unilateral facial palsy).

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PMID (PMCID)
27011649 (4782534)	OTHER
	Tangier's disease: An uncommon cause of facial weakness and non-length dependent demyelinating neuropathy.
	Nagappa M, Taly AB, Mahadevan A, Pooja M, Bindu PS, Chickabasaviah YT, Gayathri N, Sinha S. Ann Indian Acad Neurol. 2016;19(1):137-9.
	The presence of a demyelinating neuropathy on electrophysiology in a patient with predominant upper limb involvement and facial diplegia should raise the suspicion of Tangier disease.