Tangier disease

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.

Arteriosclerosis

Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity.

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PMID (PMCID)
12382407	MALE	Middle Aged
	Coronary artery bypass grafting for a patient with Tangier disease.
	Takami H, Kobayashi T, Nakagawa T, Sakurai M, Awata N, Yamashita S. Jpn J Thorac Cardiovasc Surg. 2002;50(9):383-6.
	A 56-year-old man with Tangier disease suffering from angina pectoris due to triple-vessel coronary artery disease evidenced extremely low blood high-density lipoprotein of 1 mg/dl, a specific laboratory indicator of this rare genetic disorder of lipid metabolism, considered to accompany juvenile arteriosclerosis.