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Tangier disease

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.

Hyperbilirubinemia

An increased amount of bilirubin in the blood.

Total: 1

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PMID (PMCID)
195100	MIXED_SAMPLE	Adult
	Tangier disease (alpha-lipoprotein deficiency).
	Brook JG, Lees RS, Yules JH, Cusack B. JAMA. 1977;238(4):332-4.
	A patient with asymptomatic hypocholesterolemia, mild hyperbilirubinemia, and splenomegaly was found, on lipoprotein analysis, to have Tangier disease (alpha-lipoprotein deficiency).