Tangier disease

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.

Foam cells

The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.

Total: 3

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PMID (PMCID)
7848370	MIXED_SAMPLE	Adult
	Characterization of atherosclerosis in a patient with familial high-density lipoprotein deficiency.
	Walter M, Kerber S, Fechtrup C, Seedorf U, Breithardt G, Assmann G. Atherosclerosis. 1994;110(2):203-8.
	Our findings suggest that HDL deficiency and foam cell formation in Tangier disease are not necessarily associated with accelerated development of atherosclerosis.
7848370	MIXED_SAMPLE	Adult
	Characterization of atherosclerosis in a patient with familial high-density lipoprotein deficiency.
	Walter M, Kerber S, Fechtrup C, Seedorf U, Breithardt G, Assmann G. Atherosclerosis. 1994;110(2):203-8.
	The lack of severe atherosclerosis was remarkable insofar as massive foam cell formation and the virtually complete absence of circulating HDL is characteristic of Tangier disease and has been previously demonstrated in this patient.
8053248	MALE	Middle Aged
	[Coronary angiography and intravascular ultrasound examination of a 60-year-old patient with familial HDL deficiency (Tangier disease)].
	Walter M, Kerber S, Fechtrup C, Seedorf U, Breithardt G, Assmann G. Z Kardiol. 1994;83(5):381-5.
	The lack of severe atherosclerosis was remarkable insofar as massive foam cell formation in reticuloendothelial tissues and the virtually complete absence of circulating HDL is characteristic of Tangier disease and had been previously demonstrated in this patient.