Tangier disease

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.

Cerebral amyloid angiopathy

Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system.


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(per page)
PMID (PMCID)
22133743
 FEMALE Middle Aged
Recurrent lobar intracerebral hemorrhage in Tangier disease.
Feng W, Sidorov E, Smith K, Selim M.
J Stroke Cerebrovasc Dis. 2012;21(8):909.e5-6.
This case provides new insight into the links between the adenotriphosphate-binding cassette A1 (ABCA1) transporter gene mutation in Tangier disease and apolipoprotein-E expression in the brain and supports further investigation of the potential role of ABCA1 transporter in cerebral amyloid angiopathy.
22133743
 FEMALE Middle Aged
Recurrent lobar intracerebral hemorrhage in Tangier disease.
Feng W, Sidorov E, Smith K, Selim M.
J Stroke Cerebrovasc Dis. 2012;21(8):909.e5-6.
We report a patient with familial 945-lipoprotein deficiency (Tangier disease) who presented with recurrent lobar intracerebral hemorrhages and accumulating microbleeds on T*2-weighted magnetic resonance imaging, suggestive of probable cerebral amyloid angiopathy.