Tangier disease

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.

Decreased corneal sensation

Reduced ability of the cornea to respond to stimulation.


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PMID (PMCID)
3314502
 MALE
Ocular complications of Tangier disease.
Pressly TA, Scott WJ, Ide CH, Winkler A, Reams GP.
Am J Med. 1987;83(5):991-4.
Although associated corneal clouding has been reported to produce little visual impairment, this patient with Tangier disease had corneal clouding, decreased corneal sensation, and cicatricial ectropion and experienced slowly progressive marked visual impairment.