Lead poisoning

Lead poisoning is defined as acute or chronic exposure to lead resulting in lead accumulation (blood lead concentration (BLC) >5 ug/dL) that can affect every organ system in the body and to which children are more susceptible. Clinical manifestations depend on the amount and duration of exposure and include abdominal pain, colic, constipation, lead line on gingival tissue, arthralgia, myalgia, peripheral neuropathy, fatigue, irritability, anemia, chronic nephropathy and hypertension. In children, even low levels of exposure (BLC <5 ug/dL) is reported to lead to irreversible effects such as loss of cognition, shortening of attention span, alteration of behavior, dyslexia, attention deficit disorder, hypertension, renal impairment, immunotoxicity and toxicity to the reproductive organs.

Hemolytic anemia

A type of anemia caused by premature destruction of red blood cells (hemolysis).

Total: 8

(per page)

PMID (PMCID)
21797041	MALE	Adult
	[Acute lead poisoning: a singular case of hemolytic anemia and lead colic].
	Corradi M, Goldoni M, Sabbadini F, Mutti A. Med Lav. 2011;102(3):243-9.
	[Acute lead poisoning: a singular case of hemolytic anemia and lead colic].
14620713	MALE	Adult
	Gunshot-induced plumbism in an adult male.
	Akhtar AJ, Funnye AS, Akanno J. J Natl Med Assoc. 2003;95(10):986-90.
	Our objective is to present a case of symptomatic lead toxicity (plumbism) with abdominal colic and hemolytic anemia following a gunshot wound.
10927947	MALE	Infant
	Segmental dilatation of the ileum as an unusual cause of gastrointestinal bleeding: report of one case.
	Fang SB, Lee HC, Sheu JC, Chen BF. Acta Paediatr Taiwan. 2000;41(2):93-7.
	Laboratory studies excluded coagulopathy, hemolytic anemia and lead poisoning.
8729326	MALE	Adult
	[A wine pitcher, cause of lead poisoning].
	Jouglard J, de Haro L, Arditti J, Cottin C. Presse Med. 1996;25(6):243-6.
	A 35-year-old male nurse hospitalized for recurrent episodes of intolerable abdominal pain was found to have non-hemolytic anemia and saturnism with blood lead level reaching 500 micrograms/l.
8238001	MALE	Adult
	Hemolytic anemia associated with lead poisoning from shotgun pellets and the response to Succimer treatment.
	Aly MH, Kim HC, Renner SW, Boyarsky A, Kosmin M, Paglia DE. Am J Hematol. 1993;44(4):280-3.
	Hemolytic anemia was associated with deficient erythrocyte pyrimidine 5'-nucleotidase, and lowering of the lead level corrected the deficiency, suggesting that the enzyme deficiency is responsible for the hemolysis associated with lead poisoning.
2558262	MALE	Middle Aged
	[Hemolytic anemia caused by pyrimidine 5'-nucleotidase (P5N) deficiency 15 years later. Apropos of 2 new cases of hereditary deficit and another one of lead poisoning].
	de la Serna FJ, Gilsanz F, Ricard P, Urrutia A. Med Clin (Barc). 1989;93(10):380-2.
	In the present work, we report two cases of hemolytic anemia secondary to congenital deficiency of pyrimidin 5' nucleotidase and another case secondary to lead poisoning.
6267939	MALE	Adult
	A case of lead intoxication: clinical and biochemical studies.
	Miwa S, Ishida Y, Takegawa S, Urata G, Toyoda T. Am J Hematol. 1981;11(1):99-105.
	A 23-year-old Japanese male with severe lead intoxication accompanied by hemolytic anemia was studied.
965496	MALE	Adult
	Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines.
	Valentine WN, Paglia DE, Fink K, Madokoro G. J Clin Invest. 1976;58(4):926-32.
	The findings indicate that the hemolytic anemia and increased basophilic stippling characteristic of certain cases of lead intoxication may share a common etiology with essentially identical features of the genetically determined disorder.