Familial Mediterranean fever

Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent short episodes of fever and serositis resulting in pain in the abdomen, chest, joints and muscles.

Chronic infection

Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.


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PMID (PMCID)
18336138
 FEMALE Adult
[Systemic AA amyloidosis induced by benign neoplasms].
Bestard Matamoros O, Poveda Monje R, Ibernon Vilaro M, Carrera Plans M, Grinyo Boira JM.
Nefrologia. 2008;28(1):93-8.
The later (AA), is caused by deposition of fibrils composed of fragments of the acute phase reactant serum amyloid A (SAA) and complicates chronic diseases with ongoing or recurring inflammation, namely; rheumatoid arthritis (RA), juvenile chronic polyarthritis, ankylosing spondylitis, familial periodic fever syndromes (Familial Mediterranean Fever), chronic infections and furthermore, some neoplasms (mainly renal cell carcinoma and Hodgkin's disease).