Hirschsprung disease

Hirschsprung disease (HSCR) is a congenital intestinal motility disorder that is characterized by signs of intestinal obstruction due to the presence of an aganglionic segment of variable extent in the terminal part of the colon.

Cleft lip

A gap in the lip or lips.


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PMID (PMCID)
11223858
 MIXED_SAMPLE Infant
High maternal fever during gestation and severe congenital limb disruptions.
Martinez-Frias ML, Garcia Mazario MJ, Caldas CF, Conejero Gallego MP, Bermejo E, Rodriguez-Pinilla E.
Am J Med Genet. 2001;98(2):201-3.
In humans it has been observed that infants prenatally exposed to hyperthermia presented with spina bifida, encephalocele, microphthalmia, micrognathia, external ear anomalies, cardiac defects, hypospadias, gastrointestinal defects, cleft lip and/or cleft palate, abdominal wall defects, diaphragmatic hernia, Hirschsprung disease, Mobius syndrome, oromandibular-limb hypogenesis spectrum, and spontaneous abortions.