Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Coloboma

A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa.


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PMID (PMCID)
16714935
 MALE
Multiple eyelid defects in cutaneous Langerhans cell histiocytosis.
Wat CS, Yuen HK, Tse KK, Lam DS, Chan N.
Ophthalmic Plast Reconstr Surg. 2006;22(3):216-8.
This report describes a case of cutaneous Langerhans cell histiocytosis affecting the eyelids, resulting in a coloboma-like defect.