Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).

合計: 2

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PMID (PMCID)
19097362	MALE	Adult
	[Pathogenetically complicated case of osteoporosis in a young man].
	Zofkova I. Cas Lek Cesk. 2008;147(11):574-8.
	The aim of this case study is to demonstrate the complex pathogenesis of a severe osteoporosis in a 23-year-old heavy smoker with histiocytosis X, diabetes insipidus (DI), subclinical hypogonadism and low serum levels of IGF-I.
19097362	MALE	Adult
	[Pathogenetically complicated case of osteoporosis in a young man].
	Zofkova I. Cas Lek Cesk. 2008;147(11):574-8.
	On the other hand, a direct causal association between histiocytosis X and osteoporosis was not confirmed histomorphometrically in this patient.