Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Skin rash

A red eruption of the skin.


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PMID (PMCID)
25827831
 MIXED_SAMPLE Infant, Newborn
How I treat Langerhans cell histiocytosis.
Allen CE, Ladisch S, McClain KL.
Blood. 2015;126(1):26-35.
"Langerhans cell histiocytosis" (LCH) describes a spectrum of clinical presentations ranging from a single bone lesion or trivial skin rash to an explosive disseminated disease.
15552821
 MALE Infant
Disseminated BCG infection resembling langerhans cell histiocytosis in an infant with severe combined immunodeficiency: a case report.
Culic S, Kuzmic I, Culic V, Martinic R, Kuljis D, Pranic-Kragic A, Karaman K, Jankovic S.
Pediatr Hematol Oncol. 2004;21(6):563-72.
We present a very rare congenital immunologic disease, severe combined immunodeficiency syndrome (SCID) in 6-months-old-boy with prolonged mucocutaneous candidiasis, severe anaemia, skin rash similar to the infiltrative eczema of Langerhans cell histiocytosis (LCH) and subcutaneous nodules with histiocytic infiltration.
11453455
 MIXED_SAMPLE Infant
Delayed diagnosis of pediatric Langerhans' cell histiocytosis: case report and retrospective review of pediatric cases seen at Mayo Clinic.
Jarquin-Valdivia AA, Buchhalter J.
J Child Neurol. 2001;16(7):535-8.
Our findings indicate that neurologic manifestations of Langerhans' cell histiocytosis are rare, and the combination of diabetes insipidus, ataxia, skin rash, or osseous pain should alert the clinician to the possibility of Langerhans' cell histiocytosis and avoid delayed diagnosis.
11453455
 MIXED_SAMPLE Infant
Delayed diagnosis of pediatric Langerhans' cell histiocytosis: case report and retrospective review of pediatric cases seen at Mayo Clinic.
Jarquin-Valdivia AA, Buchhalter J.
J Child Neurol. 2001;16(7):535-8.
Our findings indicate that neurologic manifestations of Langerhans' cell histiocytosis are rare, and the combination of diabetes insipidus, ataxia, skin rash, or osseous pain should alert the clinician to the possibility of Langerhans' cell histiocytosis and avoid delayed diagnosis.
8563240
 FEMALE Infant
Interleukin-2 therapy of Langerhans cell histiocytosis.
Hirose M, Saito S, Yoshimoto T, Kuroda Y.
Acta Paediatr. 1995;84(10):1204-6.
A 20-month-old girl was diagnosed with Langerhans cell histiocytosis on the basis of a seborrheic skin rash, multiple punched out bony lesions, and skin biopsy findings.