Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.

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PMID (PMCID)
25873887 (4386111)	OTHER
	Langerhans cell histiocytosis in an adult with involvement of the calvarium, cerebral cortex and brainstem: discussion of pathophysiology and rationale for the use of intravenous immune globulin.
	Dardis C, Aung T, Shapiro W, Fortune J, Coons S. Case Rep Neurol. 2015;7(1):30-8.
	We report a case of Langerhans cell histiocytosis in a 64-year-old male who presented with symptoms and signs of brain involvement, including seizures and hypopituitarism.
17566611	MALE	Adult
	[Solitary intracerebral langerhans cell histiocytosis: report of one case and literature review].
	Mathis S, Levillain P, Vandermarcq P, Gil R, Auche V, Ciron J, Neau JP. Rev Med Interne. 2007;28(9):645-50.
	We report the case of a 31 year old man hospitalized for left partial motor seizure revealing a right frontal tumor with criteria for histiocytosis X.
6606436	MALE	Child
	[Case of histiocytosis X with a large intracranial mass].
	Sakamoto N, Ichikizaki K, Komiyama M, Mikami K, Izumi C. No To Shinkei. 1983;35(10):989-99.
	The authors experienced a case of histiocytosis X with a large intracranial mass resulting in a convulsive seizure.