Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Paronychia

The nail disease paronychia is an often-tender bacterial or fungal hand infection or foot infection where the nail and skin meet at the side or the base of a finger or toenail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia).


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PMID (PMCID)
17130113
 FEMALE
Nail involvement in langerhans cell histiocytosis.
Ashena Z, Alavi S, Arzanian MT, Eshghi P.
Pediatr Hematol Oncol. 2007;24(1):45-51.
Nail involvement, which is distinctly uncommon in Langerhans cell histiocytosis (LCH), is characterized by various features like longitudinal grooving, purpuric striae, hyperkeratosis, subungual pustules, deformity, loss of nail plate, paronychia, onycholysis, and pitting.
8186123
 MALE Infant
Nail features in Langerhans cell histiocytosis.
de Berker D, Lever LR, Windebank K.
Br J Dermatol. 1994;130(4):523-7.
Nail unit changes are rare in Langerhans cell histiocytosis, and this case illustrates the range of findings, including paronychia, nail fold destruction, onycholysis with subungual expansion, and nail plate loss.