Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Pancytopenia

An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets).


合計: 2

                       


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PMID (PMCID)
27079402
 OTHER Infant, Newborn
[Langerhans cell histiocytosis with atypical and early neonatal debut].
Garcia-Rodriguez E, Bernabeu-Wittel J, Calderon-Lopez G, Pavon-Delgado A.
Arch Argent Pediatr. 2016;114(2):e104-7.
However, the most common blood disorder in Langerhans cell histiocytosis is pancytopenia rather than leukocytosis, so that the diagnosis was delayed.
22031119
 MALE Infant, Newborn
A rare case of neonatal systemic xanthogranulomatosis with severe hepatic disease and metachronous skin involvement.
Papadakis V, Volonaki E, Katsibardi K, Stefanaki K, Valari M, Anagnostakou M, Polychronopoulou S.
J Pediatr Hematol Oncol. 2012;34(3):226-8.
Rapid deterioration of liver disease and pancytopenia, prompted us to administer immunosuppressive treatment (Langerhans cell histiocytosis-II Protocol).