Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Hepatomegaly

Abnormally increased size of the liver.


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PMID (PMCID)
16819598
 MALE Infant
Liver involvement in Langerhans cell histiocytosis.
Wong A, Ortiz-Neira CL, Reslan WA, Sharon R, Pinto-Rojas A, Kaura D, Anderson R.
Pediatr Radiol. 2006;36(10):1105-7.
Liver involvement in Langerhans cell histiocytosis (LCH) typically presents with hepatomegaly and other signs of liver dysfunction.
10440912
 MALE
Expression of Fas ligand in Langerhans' cell histiocytosis: A case report of a boy with multisystem involvement.
Peng CT, Chow KC, Chang WC, Tsai CH, Lin TY, Lin SS, Chiu CF.
Am J Hematol. 1999;61(4):256-61.
We report a 2-year-old boy who was diagnosed as Langerhans' cell histiocytosis with a prominent hepatomegaly.
9492869
 MALE Adult
Hepatic nodules as single organ involvement in an adult with Langerhans cell granulomatosis. A case report.
Levy S, Capron D, Joly JP, Cordonnier C, Sevestre H, Delamarre J, Tribout B, Capron JP.
J Clin Gastroenterol. 1998;26(1):69-73.
Liver involvement manifesting as hepatomegaly in Langerhans cell granulomatosis (LCG) is well known, but the definitive diagnosis is generally possible because other organs are involved.
2180296
 MALE Middle Aged
Reversible hepatomegaly and diabetes mellitus in an adult with disseminated histiocytosis X.
Trochtenberg DS, Dessypris EN.
Am J Med Sci. 1990;299(3):179-84.
The combination of histiocytosis X, hepatomegaly, and diabetes mellitus has not been previously reported.