Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Acute leukemia

A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).


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PMID (PMCID)
18710527
(2527498)
 OTHER
Successful outcome of Langerhans cell histiocytosis complicated by therapy-related myelodysplasia and acute myeloid leukemia: a case report.
Al-Anazi KA, Alshehri A, Al-Zahrani HA, Al-Mohareb FI, Maghfoor I, Ajarim D.
Cases J. 2008;1(1):101.
High dose chemotherapy followed by an allograft may be a curative option not only for therapy-related myelodysplasia/acute leukemia, but also for frequently relapsing and poorly controlled Langerhans cell histiocytosis.
12400613
 MALE Adult
Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8; 21), 5q-, -Y karyotype.
Aslan V, Akay OM, Durak B, Kabukcuoglu S, Gulbas Z.
Leuk Lymphoma. 2002;43(8):1683-5.
Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8; 21), 5q-, -Y karyotype.
10326224
 FEMALE Infant
Occurrence of acute nonlymphoblastic leukemia in two girls after treatment of recurrent, disseminated Langerhans cell histiocytosis.
Kager L, Heise A, Minkov M, Mobius D, Kotte W, Schulte-Overberg U, Henze G, Gadner H.
Pediatr Hematol Oncol. 1999;16(3):251-6.
The occurrence of Langerhans cell histiocytosis (LCH) and acute leukemia in one individual has rarely been observed.
8469222
 MIXED_SAMPLE Child
Langerhans cell histiocytosis and acute leukemia: unusual association in two cases.
Arico M, Comelli A, Bossi G, Raiteri E, Piombo M, Egeler RM.
Med Pediatr Oncol. 1993;21(4):271-3.
Langerhans cell histiocytosis and acute leukemia: unusual association in two cases.
1743596
 FEMALE Infant
Disseminated histiocytosis with undetermined Langerhans' cells simulating an acute non lymphoid leukemia.
Miano C, Bosman C, Boldrini R, DonFrancesco A, Ceci A, Mancini S, Rosati D.
Haematologica. 1991;76(3):240-2.
The authors report on a case of disseminated Langerhans' cell histiocytosis with a clinical presentation and a bone marrow simulating, at onset, an acute leukemia non lymphoid.