Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Neoplasm

An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour).


Total: 19

                       


(per page)
PMID (PMCID)
29428448
 MIXED_SAMPLE Adult
Pulmonary Langerhans cell histiocytosis, acute myeloid leukemia, and myelofibrosis in a large family and review of the literature.
Blakley MP, Dutcher JP, Wiernik PH.
Leuk Res. 2018;67:39-44.
There is mounting evidence that Langerhans cell histiocytosis (LCH) and acute myeloid leukemia (AML) are hematopoietic neoplasms that arise from the same myeloid precursor cell.
28859038
 FEMALE Infant
Refractory LCH With Secondary Intracranial PNET: A Case Report and Review of Literature.
Chayapathi V, Mahajan A, Kalra M.
J Pediatr Hematol Oncol. 2018;40(2):e117-e120.
The occurrence of second malignant neoplasms in patients with Langerhans cell histiocytosis is infrequent but has been reported.
26608102
 MALE Young Adult
A case of Langerhans' cell histiocytosis associated with Hodgkin's lymphoma: Fine-needle aspiration cytologic and histopathological features.
Das DK, Sheikh ZA, Alansary TA, Amir T, Al-Rabiy FN, Junaid TA.
Diagn Cytopathol. 2016;44(2):128-32.
Langerhans cell histiocytosis (LCH) can be associated with a variety of malignant neoplasms, the most common being malignant lymphoma, especially Hodgkin's lymphoma (HL).
24145594
 FEMALE
Case report of intracranial Rosai-Dorfman disease.
Wahba M.
Hosp Pract (1995). 2013;41(4):83-6.
Other differential considerations, such as primary or secondary neoplasms, infections, lymphoproliferative disorders, granulomatoses, Langerhans cell histiocytosis, and lymphocyte-rich meningioma were ruled out by additional histopathologic exam.
23590692
 MALE
Langerhans cell sarcoma: a case report.
Valentin-Nogueras SM, Seijo-Montes R, Montalvan-Miro E, Sanchez JL.
J Cutan Pathol. 2013;40(7):670-5.
Neoplasms of Langerhans cells are classified into cytologically benign Langerhans cell histiocytosis and cytologically malignant Langerhans cell sarcoma.
20496290
 MALE
Langerhans cell histiocytosis of the parietal bone with epidural and extracranial expansion - case report and a review of the literature.
Mosiewicz A, Rola R, Jarosz B, Trojanowska A, Trojanowski T.
Neurol Neurochir Pol. 2010;44(2):196-203.
Langerhans cell histiocytosis is a rare neoplasm that belongs to the histiocytic and dendritic cell neoplasm group according to the 2008 WHO classification.
19602070
 FEMALE Child
Histiocyte-rich pleomorphic mastocytoma: an uncommon variant mimicking juvenile xanthogranuloma and Langerhans cell histiocytosis.
Tran DT, Jokinen CH, Argenyi ZB.
J Cutan Pathol. 2009;36(11):1215-20.
Awareness of this unusual morphologic variant is also important as the histologic features may mimic such childhood neoplasms as juvenile xanthogranuloma and Langerhans cell histiocytosis.
17874453
 MIXED_SAMPLE Child
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
Rodig SJ, Payne EG, Degar BA, Rollins B, Feldman AL, Jaffe ES, Androkites A, Silverman LB, Longtine JA, Kutok JL, Fleming MD, Aster JC.
Am J Hematol. 2008;83(2):116-21.
Langerhans cell histiocytosis (LCH) and related entities are neoplasms of unknown pathogenesis.
17874453
 MIXED_SAMPLE Child
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
Rodig SJ, Payne EG, Degar BA, Rollins B, Feldman AL, Jaffe ES, Androkites A, Silverman LB, Longtine JA, Kutok JL, Fleming MD, Aster JC.
Am J Hematol. 2008;83(2):116-21.
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
12362286
 MALE Middle Aged
Pulmonary Langerhans' cell histiocytosis (histiocytosis X) following metastasizing malignant melanoma.
Tirilomis T, Zenker D, Mirzaie M, Dalichau H.
Swiss Med Wkly. 2002;132(21-22):285-7.
Association of pulmonary Langerhans' cell histiocytosis with a malignant neoplasm is rare.
11419987
 FEMALE Adult
CD79a(+) T-cell lymphoblastic lymphoma with coexisting Langerhans cell histiocytosis.
Li S, Borowitz MJ.
Arch Pathol Lab Med. 2001;125(7):958-60.
Although there is a close association between Langerhans cell histiocytosis and malignant neoplasms, simultaneous occurrence of lymphoblastic lymphoma and Langerhans cell histiocytosis in the same lymph node is an extremely rare finding.
11419987
 FEMALE Adult
CD79a(+) T-cell lymphoblastic lymphoma with coexisting Langerhans cell histiocytosis.
Li S, Borowitz MJ.
Arch Pathol Lab Med. 2001;125(7):958-60.
Although there is a close association between Langerhans cell histiocytosis and malignant neoplasms, simultaneous occurrence of lymphoblastic lymphoma and Langerhans cell histiocytosis in the same lymph node is an extremely rare finding.
11145200
 FEMALE
September 2000: 15 year old girl with intracranial lesion.
Gutnik H, Dolenc-Strazar Z, Popovic M.
Brain Pathol. 2001;11(1):123-5.
The only specific ultra-structural finding differing JXG from histiocytic neoplasm of Langerhans' cells histiocytosis type seems to be Birbeck granules.
8431870
 MIXED_SAMPLE Infant
Association of Langerhans cell histiocytosis with malignant neoplasms.
Egeler RM, Neglia JP, Puccetti DM, Brennan CA, Nesbit ME.
Cancer. 1993;71(3):865-73.
The association of Langerhans cell histiocytosis (LCH) with a malignant neoplasm is rare and generally has been the subject of isolated case reports.
8431870
 MIXED_SAMPLE Infant
Association of Langerhans cell histiocytosis with malignant neoplasms.
Egeler RM, Neglia JP, Puccetti DM, Brennan CA, Nesbit ME.
Cancer. 1993;71(3):865-73.
Association of Langerhans cell histiocytosis with malignant neoplasms.
1571264
 FEMALE Middle Aged
Malignant Langerhans cell tumour.
Tani M, Ishii N, Kumagai M, Ban M, Sasase A, Mishima Y.
Br J Dermatol. 1992;126(4):398-403.
Langerhans cell histiocytosis is now regarded as a disorder of immune regulation or an inflammatory process, rather than as a malignant neoplasm.
1571264
 FEMALE Middle Aged
Malignant Langerhans cell tumour.
Tani M, Ishii N, Kumagai M, Ban M, Sasase A, Mishima Y.
Br J Dermatol. 1992;126(4):398-403.
Therefore, we propose designating a malignant neoplasm of LC 'malignant Langerhans cell tumour' and that it should be considered as a separate entity from Langerhans cell histiocytosis or other malignant histiocytoses.
2029064
 MIXED_SAMPLE Adult
Lymphoproliferative disorders of the head and neck.
Green JD Jr, Neel HB 3rd, Witzig TE.
Am J Otolaryngol. 1991;12(1):26-32.
Lymphoproliferative disorders may be subdivided into five categories: Hodgkin's disease, non-Hodgkin's lymphoma, histiocytosis X, benign reactive lymphoproliferative disorders, and plasma cell neoplasms.
304801
 MIXED_SAMPLE Adult
[Malignant histiocytosis (author's transl)].
Huhn D, Meister P, Thiel E, Bartl R, Theml H.
Dtsch Med Wochenschr. 1978;103(2):55-61.
Malignant histiocytosis is more like monocyte leukaemia and histiocytosis X than neoplasms of the lymphatic system.