Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Osteolysis

Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium.


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PMID (PMCID)
10414115
 MIXED_SAMPLE Adult
[Oral manifestations of Lpngerhans' cell histiocytosis. Therapeutic strategies involving oral and maxillofacial surgery].
Schultze A, Eckardt A, Kuske M.
Mund Kiefer Gesichtschir. 1999;3(3):158-64.
Oral manifestations of a Langerhans' cell histiocytosis have to be considered, especially with regard to therapy-resistant parodontopathies or with radiologically conspicuous, unexplained osteolysis.
1783557
 FEMALE Child
Langerhans' cell histiocytosis: a case report.
Pinelli G, Costa M, Gandus S, Becchetti S.
Ital J Orthop Traumatol. 1991;17(3):413-7.
They then describe a case of multifocal Langerhans' cell histiocytosis due to pelvic osteolysis and early diabetes insipidus, emphasizing the effectiveness of the combination of surgery and chemotherapy and the rapid reparative new bone formation.
3350958
 MALE
Histiocytosis X with scoliosis and osteolysis.
Wroble RR, Weinstein SL.
J Pediatr Orthop. 1988;8(2):213-8.
Severe progressive scoliosis and massive osteolysis of both femoral shafts occurred in conjunction with the Hand-Schuller-Christian form of histiocytosis X.