Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Foam cells

The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.


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PMID (PMCID)
188389
 MALE Child
Xanthoma secondary to reticulo-histiocyte infiltration.
Sato A, Tanahashi Y, Maie O, Maruhama Y.
Arch Dermatol Res. 1976;257(1):93-106.
The foam cells found in the xanthoma case with erythroderma and actinic reticuloid appeared different from those with histiocytosis X in their fine structures.