Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Combined immunodeficiency

A group of phenotypically heterogeneous genetic disorders characterized by profound deficiencies of T- and B-cell function, which predispose the patients to both infectious and noninfectious complications.


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(per page)
PMID (PMCID)
8214798
 FEMALE Infant
A 13-month-old child with chronic diarrhea, weight loss, and tachypnea.
Knutsen AP, Goodman GM.
Ann Allergy. 1993;71(4):352-6.
Conversely, patients presenting with combined immunodeficiency or common variable immune deficiency may display features of disseminated Langerhans cell histiocytosis.
8214798
 FEMALE Infant
A 13-month-old child with chronic diarrhea, weight loss, and tachypnea.
Knutsen AP, Goodman GM.
Ann Allergy. 1993;71(4):352-6.
It is known that patients with the combined immunodeficiency syndrome may present as disseminated Langerhans cell histiocytosis, and the case presented demonstrates that patients with common variable immune deficiency may similarly present.