Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Square-wave jerks

Square wave jerks are saccadic eye movements which, when recorded with open eyes are considered to be a pathological sign, caused by fixation instability, and pointing to a central neurological lesion.


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PMID (PMCID)
18078708
 MALE Middle Aged
Square-wave jerks and smooth pursuit impairment as subtle early signs of brain involvement in Langerhans' cell histiocytosis.
Anagnostou E, Papageorgiou SG, Potagas C, Alexakis T, Kalfakis N, Anastasopoulos D.
Clin Neurol Neurosurg. 2008;110(3):286-90.
Square-wave jerks and smooth pursuit impairment as subtle early signs of brain involvement in Langerhans' cell histiocytosis.