Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Granuloma

A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.


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PMID (PMCID)
24832400
 MALE Infant
A case of giant intracranial tuberculoma in an infant: clinical and radiologic pitfalls.
Raheja A, Sinha S, Sable MN, Sharma MC, Sharma BS.
J Child Neurol. 2015;30(3):364-7.
Final histopathology revealed multiple epithelioid granulomas suggestive of tubercular etiology or intracranial Langerhans cell histiocytosis.
26419115
 FEMALE Young Adult
[Anesthetic Management of a Patient with Langerhans Cell Histiocytosis during Cesarean section].
Ishii E, Takaenoki Y, Shizukuishi M, Fukuda I, Kazama T.
Masui. 2015;64(4):444-8.
Langerhans cell histiocytosis is a rare disease, associated with histiocyte increases, and granuloma, in various organs.
25433492
(4268858)
 MIXED_SAMPLE Adult
Effectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis.
Grobost V, Khouatra C, Lazor R, Cordier JF, Cottin V.
Orphanet J Rare Dis. 2014;9:191.
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder characterised by granulomatous proliferation of CD1a-positive histiocytes forming granulomas within lung parenchyma, in strong association with tobacco smoking, and which may result in chronic respiratory failure.
22682648
 FEMALE Adult
Xanthomatous hypophysitis.
Niyazoglu M, Celik O, Bakkaloglu DV, Oz B, Tanriover N, Gazioglu N, Kadioglu P.
J Clin Neurosci. 2012;19(12):1742-4.
The histological differential diagnosis includes other causes of hypophysitis, Erdheim-Chester disease (ECD), Langerhans cell histiocytosis, Rosai-Dorfman disease and plasma cell granulomas.
21368660
 FEMALE Adult
A novel heterozygous missense mutation G316D of SIX3 gene in a Brazilian patient with holoprosencephaly-like phenotype and Langerhans cell histiocytosis.
Ribeiro LA, Bertolacini CD, Quiezi RG, Richieri-Costa A.
Clin Dysmorphol. 2011;20(3):160-2.
Here we report on a Brazilian female patient with the clinical manifestations of the holoprosencephaly-like phenotype who also presented with a retroocular granuloma diagnosed as Langerhans cell histiocytosis in early infancy.
21512670
 MALE Adult
Langerhans cell histiocytosis of the lung with probably skeletal involvement.
Shih WJ, Shih GL, Milan P.
Hell J Nucl Med. 2011;14(1):65-7.
Langerhans cell histiocytosis is characterized by abnormal accumulations of large mononuclear cells forming granulomas in various organs mainly in the lung, bone, or skin.
21773662
 MALE Young Adult
[Adult pulmonary Langerhans cell histiocytosis. Report of one case].
Osses R, Gonzalez S, Aguirre M, Saldias F.
Rev Med Chil. 2011;139(2):230-5.
In adults, pulmonary involvement with Langerhans cell histiocytosis usually occurs as a single-organ disease and is characterized by focal Langerhans cell granulomas infiltrating and destroying distal bronchioles.
20811571
(2929637)
 OTHER
Unifocal Granuloma of Femur due to Langerhans' Cell Histiocytosis: A Case Report and Review of the Literature.
Singh H, Kaur S, Yuvarajan P, Jain N, Maini L.
Case Rep Med. 2010;2010:.
Unifocal Granuloma of Femur due to Langerhans' Cell Histiocytosis: A Case Report and Review of the Literature.
19192223
 MALE Middle Aged
Langerhans' cell histiocytosis mimicking metastatic carcinoma of the lung.
Niksarlioglu YO, Gurel B, Tezel GG, Firat P, Dogan R, Kars A, Coplu L.
Respirology. 2009;14(3):456-8.
Langerhans' cell histiocytosis (LCH), previously known as Histiocytosis X, is characterized by abnormal accumulations of large mononuclear cells forming granulomas in various organs, mainly bone, skin and lung.
19192223
 MALE Middle Aged
Langerhans' cell histiocytosis mimicking metastatic carcinoma of the lung.
Niksarlioglu YO, Gurel B, Tezel GG, Firat P, Dogan R, Kars A, Coplu L.
Respirology. 2009;14(3):456-8.
Langerhans' cell histiocytosis (LCH), previously known as Histiocytosis X, is characterized by abnormal accumulations of large mononuclear cells forming granulomas in various organs, mainly bone, skin and lung.
19562369
 MALE Young Adult
Pulmonary histiocytic sarcoma mimicking pulmonary Langerhans cell histiocytosis in a young adult presenting with spontaneous pneumothorax: a potential diagnostic pitfall.
Stacher E, Beham-Schmid C, Terpe HJ, Simiantonaki N, Popper HH.
Virchows Arch. 2009;455(2):187-90.
The granuloma consisted of histiocytic cells with enlarged pale nuclei, plasma cells, lymphocytes and scanty eosinophilic granulocytes giving the impression of a granuloma of pulmonary Langerhans cell histiocytosis on haematoxylin and eosin (H&E) stains.
19562369
 MALE Young Adult
Pulmonary histiocytic sarcoma mimicking pulmonary Langerhans cell histiocytosis in a young adult presenting with spontaneous pneumothorax: a potential diagnostic pitfall.
Stacher E, Beham-Schmid C, Terpe HJ, Simiantonaki N, Popper HH.
Virchows Arch. 2009;455(2):187-90.
The granuloma consisted of histiocytic cells with enlarged pale nuclei, plasma cells, lymphocytes and scanty eosinophilic granulocytes giving the impression of a granuloma of pulmonary Langerhans cell histiocytosis on haematoxylin and eosin (H&E) stains.
18330433
 OTHER
Endoscopic-Assisted Removal of Orbital Roof Lesions via a Skin Crease Approach.
Prabhakaran VC, Hsuan J, Selva D.
Skull Base. 2007;17(5):341-5.
There were two cases each of cholesterol granuloma, Langerhans' cell histiocytosis, and orbital dermoid.
17642163
 FEMALE
Unifocal langerhans cell histiocytosis presenting with pathological fracture.
Mengistu AD, Bedri A, Schneider J.
Ethiop Med J. 2007;45(1):91-3.
The patient was initially treated as a case of osteomyelitis until the diagnosis of Langerhans cell histiocytosis (histiocytosis X, eosiniphilic granuloma) was made by bone biopsy.
17642163
 FEMALE
Unifocal langerhans cell histiocytosis presenting with pathological fracture.
Mengistu AD, Bedri A, Schneider J.
Ethiop Med J. 2007;45(1):91-3.
The patient was initially treated as a case of osteomyelitis until the diagnosis of Langerhans cell histiocytosis (histiocytosis X, eosiniphilic granuloma) was made by bone biopsy.
14983135
 MIXED_SAMPLE Adult
Difficulties in the diagnosis of rare immunological diseases manifesting with cystic lung disease and spontaneous pneumothorax: Case reports.
Krawczyk P, Czekajska-Chehab E, Kieszko R, Siwiec J, Wegrzyn-Szkutnik I, Gryglicka B, Milanowski J.
Heart Lung. 2004;33(1):21-5.
Pneumothorax also precedes or complicates the clinical course of 25% of patients with Langerhans'-cell histiocytosis (LCH, histiocytosis X) pathologically characterised by involved tissue infiltration with large numbers of unusual Langerhans' cells, often organised as granulomas.
14983135
 MIXED_SAMPLE Adult
Difficulties in the diagnosis of rare immunological diseases manifesting with cystic lung disease and spontaneous pneumothorax: Case reports.
Krawczyk P, Czekajska-Chehab E, Kieszko R, Siwiec J, Wegrzyn-Szkutnik I, Gryglicka B, Milanowski J.
Heart Lung. 2004;33(1):21-5.
Pneumothorax also precedes or complicates the clinical course of 25% of patients with Langerhans'-cell histiocytosis (LCH, histiocytosis X) pathologically characterised by involved tissue infiltration with large numbers of unusual Langerhans' cells, often organised as granulomas.
11917223
 FEMALE Adult
Nodular histiocytic hyperplasia of the endometrium.
Kim KR, Lee YH, Ro JY.
Int J Gynecol Pathol. 2002;21(2):141-6.
The lesion should not be confused with a variety of reactive, inflammatory, or neoplastic conditions, such as xanthogranulomatous endometritis, malakoplakia, histiocytic granuloma, hormonal changes of the endometrial stroma, Langerhans' cell histiocytosis, morular metaplasia, extravillous trophoblast, or exaggerated placental site reaction.
12162220
 FEMALE Adult
[Interest in thalidomide in cutaneo-mucous and hypothalamo-hypophyseal involvement of Langerhans cell histiocytosis].
Claudon A, Dietemann JL, Hamman De Compte A, Hassler P.
Rev Med Interne. 2002;23(7):651-6.
Histiocytosis X or Langerhans cell granuloma is a rare disease characterised by the proliferation of phagocytes which have normal cell markers.
11070469
 FEMALE Child
Different manifestations of langerhans cell histiocytosis affecting two members of a family.
Baliko Z, Schreiner M, Kishindy KK, Hegedus G, Kosztolanyi G.
Respiration. 2000;67(5):583-5.
Two different manifestations of Langerhans cell histiocytosis (histiocytosis X) are presented, the first occurring as a solitary rib eosinophil granuloma in an 11-year-old girl, and the second as an eosinophil granuloma of the lung of her mother, a 41-year-old heavy smoker, appearing 8 years after the onset of her daughter's disease.