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Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.

Papule

A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point.

Total: 10

(per page)

PMID (PMCID)
29691886	MIXED_SAMPLE	Infant
	Cutaneous Langerhans cell histiocytosis presenting with hypopigmented lesions: Report of two cases and review of literature.
	Mori S, Adar T, Kazlouskaya V, Alexander JB, Heilman E, Glick SA. Pediatr Dermatol. 2018;35(4):502-506.
	These cases highlight the importance of including Langerhans cell histiocytosis in the differential diagnosis of an infant with hypopigmented macules and papules.
19969387	MALE	Infant
	A child with coexistent juvenile xanthogranuloma and Langerhans cell histiocytosis.
	Yu H, Kong J, Gu Y, Ling B, Xi Z, Yao Z. J Am Acad Dermatol. 2010;62(2):329-32.
	A biopsy specimen from one of the yellowish papules showed histopathologic and immunohistochemical changes of both juvenile xanthogranuloma and Langerhans cell histiocytosis.
20589477	MALE	Infant
	Congenital Langerhans cell histiocytosis with skin and lung involvement: spontaneous regression.
	Aggarwal V, Seth A, Jain M, Krishnamurthy S, Chandra V, Aneja S. Indian J Pediatr. 2010;77(7):811-2.
	Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period with eruption of multiple, discrete red-brown papules or nodules that undergo spontaneous regression.
20589477	MALE	Infant
	Congenital Langerhans cell histiocytosis with skin and lung involvement: spontaneous regression.
	Aggarwal V, Seth A, Jain M, Krishnamurthy S, Chandra V, Aneja S. Indian J Pediatr. 2010;77(7):811-2.
	Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period with eruption of multiple, discrete red-brown papules or nodules that undergo spontaneous regression.
20537086	MALE	Infant
	Langerhans cell histiocytosis presenting as hypopigmented papules.
	Mehta B, Amladi S. Pediatr Dermatol. 2010;27(2):215-7.
	Langerhans cell histiocytosis presenting as hypopigmented papules.
20537086	MALE	Infant
	Langerhans cell histiocytosis presenting as hypopigmented papules.
	Mehta B, Amladi S. Pediatr Dermatol. 2010;27(2):215-7.
	He subsequently developed multiple asymptomatic discrete hypopigmented papules on the face, trunk and extremities, which, on histology, were confirmed as Langerhans cell histiocytosis, a presentation hitherto unreported in literature.
20199460	FEMALE	Infant
	Isolated Langerhans cell histiocytosis of the vulva in an infant.
	Hwang C, Kim YJ, Seo YJ, Park JK, Lee JH, Lee Y. Pediatr Dermatol. 2009;26(6):751-3.
	We report a 1-year-old female infant with isolated Langerhans cell histiocytosis presenting as pruritic papules confined to the vulva, confirmed by histopathology with immunohistochemical staining.
17576340	MALE
	Lymphomatoid papulosis with CD1a+ dendritic cell hyperplasia, mimicking Langerhans cell histiocytosis.
	Jokinen CH, Wolgamot GM, Wood BL, Olerud J, Argenyi ZB. J Cutan Pathol. 2007;34(7):584-7.
	We present a case of a 70-year-old man with a 3-year history of recurrent red papules and plaques on the extremities and trunk that was referred to our institution, with the diagnosis of Langerhans cell histiocytosis.
9046743	MALE	Adult
	Primary cutaneous Langerhans cell histiocytosis treated with photochemotherapy.
	Kwon OS, Cho KH, Song KY. J Dermatol. 1997;24(1):54-6.
	A 23-year-old man with Langerhans cell histiocytosis presented with asymptomatic, purplish, slightly scaly, confluent papules of one year's duration.
8720257	MALE
	Satisfactory remission achieved by PUVA therapy in Langerhans cell hisiocytosis in an elderly patient.
	Sakai H, Ibe M, Takahashi H, Matsuo S, Okamoto K, Makino I, Oomori Y, Iizuka H. J Dermatol. 1996;23(1):42-6.
	We report a 74-year-old man with Langerhans cell histiocytosis who had generalized hemorrhagic and crusted papules.