Graft versus host disease

A rare disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.

Proteinuria

Increased levels of protein in the urine.


Total: 3

                       


(per page)
PMID (PMCID)
23006339
(4504137)
 FEMALE Middle Aged
Minimal change disease in graft versus host disease: a podocyte response to the graft?
Huskey J, Rivard C, Myint H, Lucia S, Smith M, Shimada M, Ishimoto T, Araya C, Garin EH, Johnson RJ.
Clin Nephrol. 2013;80(6):469-73.
We hypothesize that alloreactive donor T cells target the kidney and induce podocyte expression of CD80 that results in proteinuria from limited 'graft versus host' disease.
24288970
 MALE Middle Aged
[Complete remission of repeated recurrent membranous nephropathy after non-myeloablative allogeneic peripheral blood stem cell transplantation].
Matsuura T, Hiramoto N, Iwasa T, Shoji M, Ohashi K.
Nihon Jinzo Gakkai Shi. 2013;55(7):1327-34.
Seven months after transplantation, he suffered from nephrotic syndrome (proteinuria 16.67 g/day) around two weeks atter tapering tacrolimus (TAC) for the prophylaxis of graft-versus-host disease(GVHD).
17971194
(2174495)
 OTHER
Minimal change nephrotic syndrome after stem cell transplantation: a case report and literature review.
Silva S, Maximino J, Henrique R, Paiva A, Baldaia J, Campilho F, Pimentel P, Loureiro A.
J Med Case Rep. 2007;1:121.
After treatment with prednisolone and mycophenolate mofetil he had complete remission of proteinuria and improvement of graft-versus-host disease.