Graft versus host disease

A rare disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.

Jaundice

Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.


Total: 8

                       


(per page)
PMID (PMCID)
15553801
 FEMALE Adult
Donor lymphocyte infusion induced acute hepatitis.
You JY, Yu YB, Chen PC, Tsay SH, Chen CC, Ho CH, Chau WK, Hsu HC, Gau JP, Tzeng CH.
J Chin Med Assoc. 2004;67(8):411-5.
Hepatic graft-versus-host disease (GVHD) post allogeneic hematopoietic stem cell transplantation generally presents as cholestatic jaundice and increased serum alkaline phosphatase (ALK-P).
12702918
 FEMALE Middle Aged
Full-blown graft-versus-host disease presenting with skin manifestations, jaundice and diarrhoea: an unusual paraneoplastic phenomenon of a thymoma.
Sleijfer S, Kaptein A, Versteegh MI, Hegt VN, Snels DG, van Tilburg AJ.
Eur J Gastroenterol Hepatol. 2003;15(5):565-9.
Full-blown graft-versus-host disease presenting with skin manifestations, jaundice and diarrhoea: an unusual paraneoplastic phenomenon of a thymoma.
2293582
 FEMALE Child
Secondary biliary cirrhosis as a consequence of graft-versus-host disease.
Stechschulte DJ Jr, Fishback JL, Emami A, Bhatia P.
Gastroenterology. 1990;98(1):223-5.
Subsequent skin biopsy was consistent with cutaneous graft-versus-host disease, and biopsy-proven hepatic involvement manifested by severe, unremitting cholestatic jaundice soon followed.
3539693
 FEMALE Adult
Cirrhosis as a consequence of graft-versus-host disease.
Knapp AB, Crawford JM, Rappeport JM, Gollan JL.
Gastroenterology. 1987;92(2):513-9.
In the months after successful engraftment, she developed cutaneous and hepatic graft-versus-host disease, associated with marked cholestatic jaundice.
3523399
 MALE
Factitious hyponatremia in a patient with cholestatic jaundice following bone marrow transplantation.
Coakley JC, Vervaart PP, McKay MR.
Pathology. 1986;18(1):158-9.
Following transplantation, he developed graft-versus-host disease and obstructive jaundice.
2981167
 MIXED_SAMPLE Infant
Successful immune reconstitution in severe combined immunodeficiency despite Epstein-Barr virus and cytomegalovirus infections.
DeVoe PW, Buckley RH, Shirley LR, Darby CP, Ward FE, Mickey GH, Raab-Traub N, Vandenbark GR.
Clin Immunol Immunopathol. 1985;34(1):48-59.
At 3 weeks postgrafting, neutropenia and cholestatic jaundice developed without other signs of graft versus host disease.
19336
 MALE Child
Obstructive jaundice after bone marrow transplantation.
Lipshutz GR, Katon RM, Lee TG.
Gastroenterology. 1977;73(3):565-9.
Jaundice after bone marrow transplantation is usually a consequence of graft versus host disease.
19336
 MALE Child
Obstructive jaundice after bone marrow transplantation.
Lipshutz GR, Katon RM, Lee TG.
Gastroenterology. 1977;73(3):565-9.
The entities of graft versus host disease as related to jaundice, and gastrointestinal leukemia, in the presence of a "remission" bone marrow, are reviewed.