Graft versus host disease

A rare disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.

Splenomegaly

Abnormal increased size of the spleen.


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PMID (PMCID)
12931564
 MALE Adult
[Successful treatment of refractory peripheral T-cell lymphoma by allogeneic peripheral blood stem cell transplantation].
Shiratsuchi M, Suehiro S, Suehiro Y, Tani K, Ohshima K, Shiokawa S, Nishimura J.
Rinsho Ketsueki. 2003;44(7):456-61.
After the patient developed grade III graft-versus-host disease, his splenomegaly improved dramatically.