Graft versus host disease

A rare disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.

Schistocytosis

The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood.


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PMID (PMCID)
9844232
FEMALE Adult
[Fulminant angiopathy caused by allogenic transplantation of bone marrow with cerebral involvement: clinico-pathologic correlation].
Guerrero AL, Perez-Simon JA, Cunado A, Cacho J, Vidriales B.
An Med Interna. 1998;15(10):545-7.
After presenting graft-versus-host disease, hyperbilirubinemia, cyclosporine toxic levels, renal failure and peripheral schistocytosis, she developed complex partial seizures and bilateral hypodensity lesions in occipital lobes.