Acinar cell carcinoma of pancreas

A very rare, malignant, epithelial tumor of the pancreas characterized, macroscopically, by a usually large, well-circumscribed, fully or partially encapsulated, solid mass, often with hemorrhage, necrosis and cystic changes, in any portion of the pancreas and, histologically, by neoplastic cells with variable degrees of differentiation and morphology, ranging from acinar structures similar to normal pancreatic acini to large sheets of poorly differentiated neoplastic cells. Presenting symptoms are typically non-specific and include abdominal pain, weight loss, vomiting, nausea, and/or, less commonly, jaundice. Immunohistochemical evidence of acinar-specific products is observed. Association with Lynch syndrome, familial adenomatous polyposis, and pancreatic panniculitis has been reported.

Neoplasm

An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour).


Total: 7

                       


(per page)
PMID (PMCID)
30409114
(6225569)
 MALE
Pancreatic acinar cell carcinoma-case report and literature review.
Xing-Mao Z, Hong-Juan Z, Qing L, Qiang H.
BMC Cancer. 2018;18(1):1083.
Pancreatic acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of all pancreatic neoplasms.
29394592
 FEMALE Middle Aged
[A Difficult Diagnostic Case of Pancreatic Acinar Cell Carcinoma].
Matsui H, Sakamoto K, Matsukuma S, Tokumitsu Y, Tokuhisa Y, Kanekiyo S, Tomochika S, Iida M, Suzuki N, Takeda S, Yoshino S, Hazama S, Ueno T, Nagano H.
Gan To Kagaku Ryoho. 2017;44(12):1235-1237.
The patient was a 46-year-old woman with left lower abdominal pain.Abdominal dynamic CT revealed a 40 mm, gradually- enhanced pancreatic head mass.The interior of the tumor was heterogeneous and partly low in density.Endoscopic ultrasonography showed a well-defined and heterogeneous tumor with an echoic area in the pancreatic head.Therefore, the cystic lesion with solid components was suspected to be a solid pseudopapillary neoplasm(SPN), considering the age of the patient.Subtotal stomach-preserving pancreaticoduodenectomy was performed.The postoperative course was uneventful, and she was discharged on the 13th day after surgery.Postoperative pathology confirmed a diagnosis of pancreatic acinar cell carcinoma.SPNs often show an image very similar to pancreatic acinar cell carcinoma and it is difficult to distinguish between the two only by imaging findings.Due to the divergence between clinical findings such as age and image findings, it was difficult to confirm a diagnosis of pancreatic acinar cell carcinoma in this case.
29394592
 FEMALE Middle Aged
[A Difficult Diagnostic Case of Pancreatic Acinar Cell Carcinoma].
Matsui H, Sakamoto K, Matsukuma S, Tokumitsu Y, Tokuhisa Y, Kanekiyo S, Tomochika S, Iida M, Suzuki N, Takeda S, Yoshino S, Hazama S, Ueno T, Nagano H.
Gan To Kagaku Ryoho. 2017;44(12):1235-1237.
The patient was a 46-year-old woman with left lower abdominal pain.Abdominal dynamic CT revealed a 40 mm, gradually- enhanced pancreatic head mass.The interior of the tumor was heterogeneous and partly low in density.Endoscopic ultrasonography showed a well-defined and heterogeneous tumor with an echoic area in the pancreatic head.Therefore, the cystic lesion with solid components was suspected to be a solid pseudopapillary neoplasm(SPN), considering the age of the patient.Subtotal stomach-preserving pancreaticoduodenectomy was performed.The postoperative course was uneventful, and she was discharged on the 13th day after surgery.Postoperative pathology confirmed a diagnosis of pancreatic acinar cell carcinoma.SPNs often show an image very similar to pancreatic acinar cell carcinoma and it is difficult to distinguish between the two only by imaging findings.Due to the divergence between clinical findings such as age and image findings, it was difficult to confirm a diagnosis of pancreatic acinar cell carcinoma in this case.
29394592
 FEMALE Middle Aged
[A Difficult Diagnostic Case of Pancreatic Acinar Cell Carcinoma].
Matsui H, Sakamoto K, Matsukuma S, Tokumitsu Y, Tokuhisa Y, Kanekiyo S, Tomochika S, Iida M, Suzuki N, Takeda S, Yoshino S, Hazama S, Ueno T, Nagano H.
Gan To Kagaku Ryoho. 2017;44(12):1235-1237.
The patient was a 46-year-old woman with left lower abdominal pain.Abdominal dynamic CT revealed a 40 mm, gradually- enhanced pancreatic head mass.The interior of the tumor was heterogeneous and partly low in density.Endoscopic ultrasonography showed a well-defined and heterogeneous tumor with an echoic area in the pancreatic head.Therefore, the cystic lesion with solid components was suspected to be a solid pseudopapillary neoplasm(SPN), considering the age of the patient.Subtotal stomach-preserving pancreaticoduodenectomy was performed.The postoperative course was uneventful, and she was discharged on the 13th day after surgery.Postoperative pathology confirmed a diagnosis of pancreatic acinar cell carcinoma.SPNs often show an image very similar to pancreatic acinar cell carcinoma and it is difficult to distinguish between the two only by imaging findings.Due to the divergence between clinical findings such as age and image findings, it was difficult to confirm a diagnosis of pancreatic acinar cell carcinoma in this case.
26456669
 FEMALE Middle Aged
Multimodal approach and long-term survival in a patient with recurrent metastatic acinar cell carcinoma of the pancreas: A case report.
Jauch SF, Morris VK, Jensen CT, Kaseb AO.
Pancreatology. 2016;16(1):153-6.
Pancreatic acinar cell carcinoma is an uncommon neoplasm of the exocrine pancreas associated with a poor prognosis, especially when found to be metastatic.
27403122
(4929393)
 OTHER
Pancreatic Acinar Cell Carcinoma.
Bechade D, Desjardin M, Salmon E, Desolneux G, Becouarn Y, Evrard S, Fonck M.
Case Rep Gastroenterol. 2016;10(1):174-80.
Pancreatic acinar cell carcinoma (ACC) is a rare malignant neoplasm that accounts for 1-2% of all pancreatic neoplasms.
27403122
(4929393)
 OTHER
Pancreatic Acinar Cell Carcinoma.
Bechade D, Desjardin M, Salmon E, Desolneux G, Becouarn Y, Evrard S, Fonck M.
Case Rep Gastroenterol. 2016;10(1):174-80.
Pancreatic acinar cell carcinoma (ACC) is a rare malignant neoplasm that accounts for 1-2% of all pancreatic neoplasms.