Acinar cell carcinoma of pancreas

A very rare, malignant, epithelial tumor of the pancreas characterized, macroscopically, by a usually large, well-circumscribed, fully or partially encapsulated, solid mass, often with hemorrhage, necrosis and cystic changes, in any portion of the pancreas and, histologically, by neoplastic cells with variable degrees of differentiation and morphology, ranging from acinar structures similar to normal pancreatic acini to large sheets of poorly differentiated neoplastic cells. Presenting symptoms are typically non-specific and include abdominal pain, weight loss, vomiting, nausea, and/or, less commonly, jaundice. Immunohistochemical evidence of acinar-specific products is observed. Association with Lynch syndrome, familial adenomatous polyposis, and pancreatic panniculitis has been reported.

Aspiration

Inspiration of a foreign object into the airway.


Total: 6

                      


(per page)
PMID (PMCID)
29331883
(5771966)
OTHER
Curative distal pancreatectomy in patients with acinar cell carcinoma of pancreas diagnosed by endoscopic aspiration via esophago-jejunostomy: A successful case report.
Hamada T, Nanashima A, Hiyoshi M, Ikenoue M, Imamura N, Yano K, Fujii Y, Kubota Y, Ban T, Kawakami H, Sato Y.
Int J Surg Case Rep. 2018;42:274-279.
Curative distal pancreatectomy in patients with acinar cell carcinoma of pancreas diagnosed by endoscopic aspiration via esophago-jejunostomy: A successful case report.
27634114
MALE Adult
Metastatic pancreatic acinar cell carcinoma in a younger male with marked AFP production: A potential pitfall on fine needle aspiration biopsy.
Valente K, Yacoub G, Cappellari JO, Parks G.
Diagn Cytopathol. 2017;45(2):133-136.
Metastatic pancreatic acinar cell carcinoma in a younger male with marked AFP production: A potential pitfall on fine needle aspiration biopsy.
17196112
(1779360)
OTHER
Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings.
Peng HQ, Darwin P, Papadimitriou JC, Drachenberg CB.
Cytojournal. 2006;3:29.
We describe a case of pancreatic acinar cell carcinoma with unusual cytomorphologic features mimicking an endocrine tumor of pancreas, encountered in endoscopic ultrasound-guided fine needle aspiration of a metastatic liver mass and discuss the diagnostic approach for this unusual pancreatic tumor in fine needle aspiration cytology.
17196112
(1779360)
OTHER
Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings.
Peng HQ, Darwin P, Papadimitriou JC, Drachenberg CB.
Cytojournal. 2006;3:29.
We describe a case of pancreatic acinar cell carcinoma with unusual cytomorphologic features mimicking an endocrine tumor of pancreas, encountered in endoscopic ultrasound-guided fine needle aspiration of a metastatic liver mass and discuss the diagnostic approach for this unusual pancreatic tumor in fine needle aspiration cytology.
12112815
MALE
Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas.
Ohori NP, Khalid A, Etemad B, Finkelstein SD.
Diagn Cytopathol. 2002;27(1):42-6.
Fine-needle aspiration diagnosis of pancreatic acinar cell carcinoma (PAC) is challenging.
12112815
MALE
Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas.
Ohori NP, Khalid A, Etemad B, Finkelstein SD.
Diagn Cytopathol. 2002;27(1):42-6.
Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas.