Leishmaniasis

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration).

Splenomegaly

Abnormal increased size of the spleen.


Total: 29

                       


(per page)
PMID (PMCID)
27030189
 FEMALE Middle Aged
[Visceral leishmaniasis concurrent with splenic marginal zone B-cell lymphoma].
Julhakyan UL, Magomedova AU, Dvirnyk VN, Kravchenko SK.
Ter Arkh. 2016;88(2):78-80.
The authors describe Russia's first case of SMZBCL concurrent with visceral leishmaniasis in a 52-year-old female patient admitted to a hematology hospital with weakness, splenomegaly, and lymphadenopathy.
26776600
 FEMALE Infant
[Visceral leishmaniasis without splenomegaly. A pediatric case report].
Leblanc C, Nouar D, Izri A, Brun S, Marty P, Gaudelus J, De Pontual L.
Arch Pediatr. 2016;23(4):378-81.
To our knowledge, this is the first case of visceral leishmaniasis without splenomegaly reported to date.
26776600
 FEMALE Infant
[Visceral leishmaniasis without splenomegaly. A pediatric case report].
Leblanc C, Nouar D, Izri A, Brun S, Marty P, Gaudelus J, De Pontual L.
Arch Pediatr. 2016;23(4):378-81.
We report a case of visceral leishmaniasis in a 21-month-old child complicated by a macrophage activation syndrome without splenomegaly.
26776600
 FEMALE Infant
[Visceral leishmaniasis without splenomegaly. A pediatric case report].
Leblanc C, Nouar D, Izri A, Brun S, Marty P, Gaudelus J, De Pontual L.
Arch Pediatr. 2016;23(4):378-81.
[Visceral leishmaniasis without splenomegaly.
25755910
 OTHER
Imported visceral leishmaniasis - unexpected bone marrow diagnosis in a patient with fever, pancytopenia, and splenomegaly.
Gallina V, Binazzi R, Golemi A, Farsad M, Weiss G, Wiedermann CJ.
Am J Blood Res. 2014;4(2):101-5.
Imported visceral leishmaniasis is likely to be seen more frequently in non-endemic regions and fever, pancytopenia and splenomegaly are diagnostic clues, whereas diagnostic confirmation may be done by detection of Leishmania spp.
25755910
 OTHER
Imported visceral leishmaniasis - unexpected bone marrow diagnosis in a patient with fever, pancytopenia, and splenomegaly.
Gallina V, Binazzi R, Golemi A, Farsad M, Weiss G, Wiedermann CJ.
Am J Blood Res. 2014;4(2):101-5.
Imported visceral leishmaniasis - unexpected bone marrow diagnosis in a patient with fever, pancytopenia, and splenomegaly.
25269966
 MALE
Visceral leishmaniasis in a psoriatic arthritis patient treated with methotrexate.
Hadjipetrou A, Anyfantakis D, Gkogkou A, Palla K, Lagoudaki E, Milonaki T, Kastanakis S.
Infez Med. 2014;22(3):230-5.
Here we describe a case of visceral leishmaniasis infection in a 65-year old Greek male with psoriatic arthritis treated with methotrexate, who presented with high grade fever, chills, splenomegaly, pancytopenia and polyclonal hypergammaglobulinaemia.
23682278
(3655258)
 OTHER
Bone marrow negative visceral leishmaniasis in an adolescent male.
Jetley S, Rana S, Khan S, Zeeba J, Hassan M, Kapoor P.
Iran J Parasitol. 2013;8(1):182-5.
In endemic areas, the constellation of fever, progressive weight loss, weakness, pronounced splenomegaly, anemia, leukopenia, and hypergammaglobulinemia is highly suggestive of visceral leishmaniasis.
23777708
 MIXED_SAMPLE Child
Leishmaniasis during anti-tumor necrosis factor therapy: report of 4 cases and review of the literature (additional 28 cases).
Guedes-Barbosa LS, Pereira da Costa I, Fernandes V, Henrique da Mota LM, de Menezes I, Aaron Scheinberg M.
Semin Arthritis Rheum. 2013;43(2):152-7.
Cutaneous lesions, prolonged fever, splenomegaly, and pancytopenias, the main clinical-laboratory findings of leishmaniasis, can also be present in autoimmune rheumatic disease, thus leading to delayed diagnosis and treatment of the parasitic disease.
26157823
(4435270)
 OTHER
Visceral Leishmania as Unusual Cause of Splenic Peliosis in the United States.
Ghazzawi Y, Absah I.
ACG Case Rep J. 2013;1(1):61-3.
Visceral leishmaniasis should be considered in cases of marked splenomegaly, anemia, and thrombocytopenia, especially with a history of visiting an endemic area.
22393633
 MALE Child
[Visceral leishmaniasis: pediatric case report observed outside the traditional foci in Cameroon].
Mbassi Awa HD, Pondy A, Njiki Kinkela M, Lebela J, Koki Ndombo PO.
Med Trop (Mars). 2011;71(6):618-20.
The purpose of this report is to describe an autochtonous case of visceral leishmaniasis with cachexia, fever, splenomegaly, ascitis and severe anemia observed in an eight-year-old boy from a region in eastern Cameroon outside the traditional disease foci.
20597048
 FEMALE Infant
[Case report: the efficacy of amphotericin B in visceral leishmaniasis].
Gulec SG, Kizilyer Y, Karaman S, Erdem E, Urganci N.
Turkiye Parazitol Derg. 2010;34(2):73-5.
In our country, visceral leishmaniasis should be considered in all age groups who live in western regions and have no history of travel and contact, that present with pancytopenia or bicytopenia, even if massive splenomegaly is absent.
18219460
 MALE
[Fever, pancytopenia, and splenomegaly 8 months after a trip to Majorca Island (Spain)].
Lubbert C, Opitz BM, Harms-Zwingenberger G, Nietsch HH.
Med Klin (Munich). 2008;103(1):29-35.
Visceral leishmaniasis is an important differential diagnosis for the clinical triad of fever, pancytopenia, and splenomegaly.
17896607
 MIXED_SAMPLE Infant
Profile of fatal visceral leishmaniasis at an Indian tertiary care center.
Malatesha G, Mathur P, Madan K, Samanta P, Samantaray JC.
Trop Gastroenterol. 2007;28(1):28-31.
Visceral leishmaniasis is a highly morbid and incapacitating infection, which usually presents with prolonged fever, weight loss and hepato-splenomegaly.
17119679
 MALE
Presence of Leishmania amastigotes in peritoneal fluid of a dog with leishmaniasis from Alagoas, Northeast Brazil.
Dantas-Torres F.
Rev Inst Med Trop Sao Paulo. 2006;48(4):219-21.
Physical examination of an adult male rottweiler suspected to be suffering of leishmaniasis revealed severe loss of weight, ascitis, splenomegaly, moderately enlarged lymph nodes, onychogryphosis, generalized alopecia, skin ulcers on the posterior limbs, and conjunctivitis.
15316302
 MIXED_SAMPLE Infant
[Mediterranean visceral leishmaniasis in immunocompetent children. Report of two cases relapsed after specific therapy].
Colomba C, Scarlata F, Salsa L, Frasca Polara V, Titone L.
Infez Med. 2004;12(2):139-43.
Both patients lived in endemic areas for leishmaniasis (Sicily) and at admission were febrile, pale and had splenomegaly.
14618961
 MALE Infant
Visceral leshmaniasis diagnosed on duodenal biopsy in a child.
Boukthir S, Mejri A, M'rad S, Barsaoui S.
Acta Gastroenterol Belg. 2003;66(3):258-9.
Visceral leishmaniasis is usually easy to recognize when clinical presentation is complete: splenomegaly, fever and palor associated to pancytopenia, hypoalbuminaemia and hypergamma globulinemia.
12931491
 MALE Adult
[Visceral leishmaniasis as a rare cause of a fever of unknown origin associated with splenomegaly].
Brzostek T, Undas R.
Pol Arch Med Wewn. 2003;109(4):395-9.
[Visceral leishmaniasis as a rare cause of a fever of unknown origin associated with splenomegaly].
11821748
 MALE Adult
Visceral Leishmaniasis in renal transplant recipients: is it still a challenge to the nephrologist?
Sabbatini M, Pisani A, Ragosta A, Gallo R, Borrelli F, Cianciaruso B.
Transplantation. 2002;73(2):299-301.
A case of visceral Leishmaniasis in a renal transplant recipient is reported because of its peculiar clinical presentation: the presence of most clinical signs of the disease, such as high-grade fever, marked leucopenia, and splenomegaly, but persistent negativity of serology and of bone marrow smear.
11760174
 MALE Infant
Splenic granulomatous lesions in immunocompetent pediatric patients with visceral leishmaniasis.
Fretzayas A, Moustaki M, Kitsiou S, Mathioudakis J, Karpathios T.
Scand J Infect Dis. 2001;33(11):865-7.
Visceral focal lesions are rarely encountered in patients with leishmaniasis despite the fact that splenomegaly, and to a lesser extent hepatomegaly, predominate among the clinical features of the disease.