Leishmaniasis

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration).

Hemophagocytosis

Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues.


Total: 9

                       


(per page)
PMID (PMCID)
19535493
 MALE Adult
Immune reconstitution visceral leishmaniasis presented as hemophagocytic syndrome in a patient with AIDS from a nonendemic area: a case report.
Patel KK, Patel AK, Sarda P, Shah BA, Ranjan R.
J Int Assoc Physicians AIDS Care (Chic). 2009;8(4):217-20.
Hemophagocytosis is known to occur with various infectious agents like viruses, bacteria, and parasites, but is rare to occur with leishmaniasis.
17700207
 MALE
Diagnostic dilemma in an adolescent boy: hemophagocytic syndrome in association with kala azar.
Celik U, Alabaz D, Alhan E, Bayram I, Celik T.
Am J Med Sci. 2007;334(2):139-41.
This is the first reported association between hemophagocytosis and visceral leishmaniasis in an adolescent.
15235168
 FEMALE Infant
Hemophagocytic syndrome associated with visceral leishmaniasis.
Kocak N, Eren M, Yuce A, Gumruk F.
Indian Pediatr. 2004;41(6):605-7.
A child with visceral leishmaniasis causing hemophagocytosis is presented.
10730157
 MALE Infant
[Syndrome of inappropriate macrophage activation associated with infantile visceral leishmaniasis].
Thabet F, Tabarki B, Fehem R, Yacoub M, Selmi H, Essoussi AS.
Tunis Med. 1999;77(12):648-50.
Hemophagocytosis has already been in cases of visceral leishmaniasis and thus may complicate search for diagnosis.
8949350
 MALE
[Infantile visceral leishmaniasis: difficult diagnosis in cases complicated by hemophagocytosis].
Nadrid A, Pousse H, Laradi-Chebil S, Khelif A, Bejaoui M, Besbes A, Radhouane M, Guediche MN.
Arch Pediatr. 1996;3(9):881-3.
After three months of clinical deterioration and apparition of active hemophagocytosis, both bone marrow aspiration and specific serology for visceral leishmaniasis became positive.
8949350
 MALE
[Infantile visceral leishmaniasis: difficult diagnosis in cases complicated by hemophagocytosis].
Nadrid A, Pousse H, Laradi-Chebil S, Khelif A, Bejaoui M, Besbes A, Radhouane M, Guediche MN.
Arch Pediatr. 1996;3(9):881-3.
Hemophagocytosis has already been reported in cases of visceral leishmaniasis and thus may complicate search for diagnosis.
8949350
 MALE
[Infantile visceral leishmaniasis: difficult diagnosis in cases complicated by hemophagocytosis].
Nadrid A, Pousse H, Laradi-Chebil S, Khelif A, Bejaoui M, Besbes A, Radhouane M, Guediche MN.
Arch Pediatr. 1996;3(9):881-3.
[Infantile visceral leishmaniasis: difficult diagnosis in cases complicated by hemophagocytosis].
8949350
 MALE
[Infantile visceral leishmaniasis: difficult diagnosis in cases complicated by hemophagocytosis].
Nadrid A, Pousse H, Laradi-Chebil S, Khelif A, Bejaoui M, Besbes A, Radhouane M, Guediche MN.
Arch Pediatr. 1996;3(9):881-3.
Diagnosis of visceral leishmaniasis may be difficult, even in countries where this condition is relatively frequent; the association with hemophagocytosis is possible and does not constitute a poor factor of prognosis if specific therapy is proposed.
6719046
 MALE
Cold agglutinin syndrome and hemophagocytosis in systemic leishmaniasis.
Kokkini G, Vrionis G, Liosis G, Papaefstathiou J.
Scand J Haematol. 1984;32(4):441-5.
Cold agglutinin syndrome and hemophagocytosis in systemic leishmaniasis.