Leishmaniasis

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration).

Severe infection

A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection.


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PMID (PMCID)
27523470
 FEMALE Middle Aged
Visceral leishmaniasis in a rheumatoid arthritis patient receiving methotrexate.
Reina D, Cerda D, Guell E, Martinez Montauti J, Pineda A, Corominas H.
Reumatol Clin. 2017;13(6):354-356.
Patients with rheumatoid arthritis (RA) treated with disease-modifying antirheumatic drugs are susceptible to severe infections such as leishmaniasis.
23884748
 MALE Middle Aged
[Severe oral mucositis in a patient with HIV infection].
Ehlert N, Seilmaier M, Guggemos W, Loscher T, Meurer A, Wendtner CM.
Dtsch Med Wochenschr. 2013;138(31-32):1601-5.
Leishmaniasis is a severe infection in HIV-positive patients.
23021706
(3481428)
 MALE
Detection of Leishmania parasites in the testis of a dog affected by orchitis: case report.
Manna L, Paciello O, Morte RD, Gravino AE.
Parasit Vectors. 2012;5:216.
Transmission of canine leishmaniasis (CanL), a severe infection caused by L. infantum, usually occurs through the sand fly bite to the vertebrate host.
10879644
 MALE Adult
Visceral leishmaniasis and other severe infections in an adult patient with p47-phox-deficient chronic granulomatous disease.
Asensi V, Tricas L, Meana A, Roos D, Carton JA, Maradona JA, Fresno MF, Valle E, Fierer J, Arribas JM.
Infection. 2000;28(3):171-4.
Visceral leishmaniasis and other severe infections in an adult patient with p47-phox-deficient chronic granulomatous disease.