Leishmaniasis

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration).

Granuloma

A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.

Total: 16

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PMID (PMCID)
29869609	OTHER
	Case Report: Mucosal Leishmaniasis Presenting with Nasal Septum Perforation after Almost Thirty Years.
	Rojas-Jaimes J, Frischtak HL, Arenas J, Lescano AG. Am J Trop Med Hyg. 2018;99(2):327-330.
	Mucosal leishmaniasis (ML) is associated with progressive tissue destruction and granuloma formation, often after a considerable period of latency from an initial cutaneous infection.
28914333	MIXED_SAMPLE	Infant, Newborn
	[Acute skin infections and their imitators in children : A photo quiz].
	Theiler M, Schwieger-Briel A, Weibel L. Hautarzt. 2017;68(10):774-783.
	The following infectious skin conditions and imitators are described and clinical clues for differentiation highlighted: eczema herpeticum and bacterial superinfection of atopic dermatitis; exanthematous hand, foot and mouth disease and varicella infection; erythema chronicum multilocularis and anular urticaria; Gianotti-Crosti syndrome and Gianotti-Crosti-like reaction; bacterial folliculitis of the scalp and kerion celsi and eosinophilic pustular folliculitis of the scalp; cutaneous Leishmaniasis and idiopathic facial aseptic granuloma; allergic and bacterial lymphangitis; bullous impetigo contagiosa and nonaccidental scalding.
26246830 (4522308)	OTHER
	Hoarseness as the Presenting Symptom of Visceral Leishmaniasis with Muco-Cutaneous Lesions: A Case Report.
	Mortazavi H, Mohebali M, Taslimi Y, Sadeghipour P, Ansari M, Kamyab K, Talebi M, Khamesipour A. Iran J Parasitol. 2015;10(2):296-300.
	The biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the dermis by lymphoplasma and histiocytic cells with a loose granuloma formation suggestive of leishmaniasis.
26632940	MALE	Adult
	Paronychia-like cutaneous leishmaniasis.
	Chiheb S, El Machbouh L, Marnissi F. Dermatol Online J. 2015;21(11):.
	The histopathological exam showed epithelioid granulomas with giant cells and the presence of leshmania amastigotes, leading to the diagnosis of ungueal leishmaniasis.
23031374	FEMALE	Middle Aged
	Cutaneous leishmaniasis with histopathologic pattern of non-necrotizing granulomatous dermatitis in patients treated with adalimumab.
	Romero-Mate A, Martinez-Sanchez D, Tardio JC, Moreno-Torres A, Garcia-Donoso C, Aguado-Lobo M, Espinosa-Lara P, Borbujo J. Dermatol Online J. 2012;18(9):7.
	In the context of a leishmaniasis outbreak in the town of Fuenlabrada, Madrid, Spain, we had two patients with cutaneous leishmaniasis that developed non-necrotizing cutaneous granulomas.
23031374	FEMALE	Middle Aged
	Cutaneous leishmaniasis with histopathologic pattern of non-necrotizing granulomatous dermatitis in patients treated with adalimumab.
	Romero-Mate A, Martinez-Sanchez D, Tardio JC, Moreno-Torres A, Garcia-Donoso C, Aguado-Lobo M, Espinosa-Lara P, Borbujo J. Dermatol Online J. 2012;18(9):7.
	In the context of a leishmaniasis outbreak in the town of Fuenlabrada, Madrid, Spain, we had two patients with cutaneous leishmaniasis that developed non-necrotizing cutaneous granulomas.
23259086 (3504292)	OTHER
	Panniculitis is an important feature of cutaneous leishmaniasis pathology.
	Sharquie KE, Hameed AF. Case Rep Dermatol Med. 2012;2012:612434.
	Cutaneous leishmaniasis is an inflammatory parasitic infection characterized by superficial and deep perivascular infiltration with or without granuloma formation.
21382292	MALE	Middle Aged
	Granulomatous rosacea: unusual presentation as solitary plaque.
	Batra M, Bansal C, Tulsyan S. Dermatol Online J. 2011;17(2):9.
	Sarcoidosis, Hansen disease, lupus vulgaris, cutaneous leishmaniasis, pseudolymphoma, foreign body granuloma, granuloma faciale, discoid lupus erythematosus, and granulomatous rosacea were considered in the differential diagnosis.
21382292	MALE	Middle Aged
	Granulomatous rosacea: unusual presentation as solitary plaque.
	Batra M, Bansal C, Tulsyan S. Dermatol Online J. 2011;17(2):9.
	Sarcoidosis, Hansen disease, lupus vulgaris, cutaneous leishmaniasis, pseudolymphoma, foreign body granuloma, granuloma faciale, discoid lupus erythematosus, and granulomatous rosacea were considered in the differential diagnosis.
20465612	MALE	Adult
	Fish tank granuloma: misdiagnosed as cutaneous leishmaniasis.
	AlKhodair R, Al-Khenaizan S. Int J Dermatol. 2010;49(1):53-5.
	Fish tank granuloma: misdiagnosed as cutaneous leishmaniasis.
12121562	FEMALE
	Unusual location of cutaneous leishmaniasis on the hallux in a Brazilian patient.
	Ogawa MM, Macedo FS, Alchorne MM, Tomimori-Yamashita J. Int J Dermatol. 2002;41(7):439-40.
	A biopsy was taken and the histologic picture showed a chronic inflammatory change with tuberculoid-type granuloma and necrosis suggesting leishmaniasis, although parasites were not observed.
8044309	MALE	Adult
	A patient with hepatic granuloma formation and angiotensin-converting enzyme production by granuloma cells during clinical relapse of hepatitis A.
	Inuzuka S, Ueno T, Tateishi H, Torimura T, Sata M, Tanikawa K, Kojiro M. Pathol Int. 1994;44(5):391-7.
	In addition, other diseases associated with the presence of granulomas in the liver, such as lymphoma, cytomegalovirus infection, visceral leishmaniasis, and lupoid hepatitis, were ruled out.
7949483	MALE	Adult
	Mucocutaneous leishmaniasis and HIV.
	Miralles ES, Nunez M, Hilara Y, Harto A, Moreno R, Ledo A. Dermatology. 1994;189(3):275-7.
	A patient with centrofacial granuloma was diagnosed as having mucocutaneous leishmaniasis; simultaneously HIV infection was detected.
8514044	MALE
	Hepatic fibrin-ring granulomas in giant cell arteritis.
	de Bayser L, Roblot P, Ramassamy A, Silvain C, Levillain P, Becq-Giraudon B. Gastroenterology. 1993;105(1):272-3.
	Other diseases usually associated with fibrin-ring granulomas in liver, such as Q fever, cytomegalovirus hepatitis, infectious mononucleosis, Hodgkin's disease, non-Hodgkin's lymphoma, allopurinol treatment, and visceral leishmaniasis, were ruled out.
1983832	MALE	Adult
	Hepatic fibrin-ring granulomas in a patient with hepatitis A.
	Ponz E, Garcia-Pagan JC, Bruguera M, Bruix J, Rodes J. Gastroenterology. 1991;100(1):268-70.
	Other causes associated with the presence of fibrin-ring granulomas in the liver, such as Hodgkin's and non-Hodgkin's lymphoma, cytomegalovirus infection, visceral leishmaniasis, and consumption of allopurinol, were ruled out.
1163553	MALE	Adult
	Imported mucocutaneous leishmaniasis in New York City. Report of a patient treated with amphotericin B.
	Singer C, Armstrong D, Jones TC, Spiro RH. Am J Med. 1975;59(3):444-7.
	A case of mococutaneous leishmaniasis in a patient referred to Memorial Sloan-Kettering Cancer Center, New York, with a presumptive diagnosis of lethal mid-line granuloma is described.