Leishmaniasis

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration).

Skin ulcer

A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat.


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PMID (PMCID)
26483124
 FEMALE Adult
A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection.
Guimaraes LH, Saldanha M, Menezes T, Moreno L, Torres A, Costa R, Passos S, Badaro R, Arruda S, Carvalho LP.
Am J Trop Med Hyg. 2015;93(6):1219-23.
Herein, we show that despite the absence of Leishmania-driven TNF, a cutaneous leishmaniasis patient with acquired immunodeficiency syndrome developed a skin ulcer.
26483124
 FEMALE Adult
A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection.
Guimaraes LH, Saldanha M, Menezes T, Moreno L, Torres A, Costa R, Passos S, Badaro R, Arruda S, Carvalho LP.
Am J Trop Med Hyg. 2015;93(6):1219-23.
Skin ulcer development in cutaneous leishmaniasis due to Leishmania braziliensis infection is associated with a mononuclear cell infiltrate and high levels of tumor necrosis factor (TNF).
17119679
 MALE
Presence of Leishmania amastigotes in peritoneal fluid of a dog with leishmaniasis from Alagoas, Northeast Brazil.
Dantas-Torres F.
Rev Inst Med Trop Sao Paulo. 2006;48(4):219-21.
Physical examination of an adult male rottweiler suspected to be suffering of leishmaniasis revealed severe loss of weight, ascitis, splenomegaly, moderately enlarged lymph nodes, onychogryphosis, generalized alopecia, skin ulcers on the posterior limbs, and conjunctivitis.