Leprechaunism

Leprechaunism is a congenital form of extreme insulin resistance (a group of syndromes that also includes Rabson-Mensenhall syndrome, type A insulin-resistance syndrome, and acquired type B insulin-resistance syndrome; see these terms) characterized by intrauterine and mainly postnatal severe growth retardation.

Micrognathia

Developmental hypoplasia of the mandible.


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PMID (PMCID)
17172088
 MALE Infant, Newborn
Some effect of metformin on insulin resistance in an infant with leprechaunism.
Atabek ME, Pirgon O.
J Pediatr Endocrinol Metab. 2006;19(10):1257-61.
Leprechaunism was first recognized in 1954 and is characterized by severe intrauterine and postnatal growth retardation, failure to thrive, lipoatrophy, dysmorphic features (globular eyes, large ears, and micrognathia), hirsutism and acanthosis nigricans.