Leptospirosis

Leptospirosis is an anthropozoonosis caused by spiral-shaped bacteria belonging to the genus Leptospira. Leptospirosis is a widespread zoonosis with a worldwide distribution and has emerged as a major public health problem in developing countries in South-East Asia and South America.

Jaundice

Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.


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PMID (PMCID)
28489846
 MALE Middle Aged
[Gastrointestinal bleeding and acute hepatic failure by leptospirosis: an entity that should not be forgotten].
Alventosa Mateu C, Plana Campos L, Larrey Ruiz L, Acedo Mayordomo R, Sanchis Artero L, Peno Munoz L, Nunez Martinez PC, Castillo Lopez GA, Latorre Sanchez M, Urquijo Ponce JJ, Diago Madrid M, Garcia-Arguelles JS.
Rev Gastroenterol Peru. 2017;37(1):96-99.
Weil's disease is a kind of severe leptospirosis characterized by hepatic failure with jaundice and acute renal failure, associated with high mortality rates.The diagnosis is based on serological techniques and DNA detection by PCR.
28489846
 MALE Middle Aged
[Gastrointestinal bleeding and acute hepatic failure by leptospirosis: an entity that should not be forgotten].
Alventosa Mateu C, Plana Campos L, Larrey Ruiz L, Acedo Mayordomo R, Sanchis Artero L, Peno Munoz L, Nunez Martinez PC, Castillo Lopez GA, Latorre Sanchez M, Urquijo Ponce JJ, Diago Madrid M, Garcia-Arguelles JS.
Rev Gastroenterol Peru. 2017;37(1):96-99.
Unusually, leptospirosis presents with a first phase with fever, myalgias, liver injury or different organs hemorrhage, followed by a second phase with the presence of jaundice due to hepatic failure.
26671230
 MALE Middle Aged
A first report of leptospirosis after liver transplantation.
Song AT, Abas L, Andrade LC, Andraus W, D'Albuquerque LA, Abdala E.
Transpl Infect Dis. 2016;18(1):137-40.
We report the first case to our knowledge of leptospirosis in a liver transplant recipient who developed jaundice and renal insufficiency.
27976565
 MALE Child
Different clinical spectrum of leptospirosis.
Aygun FD, Avar-Aydn PO, Cokugras H, Camcoglu Y.
Turk J Pediatr. 2016;58(2):212-215.
Leptospirosis should be considered in any patient presenting with an abrupt onset or prolonged fever, myalgia, headache and jaundice.
26538786
(4628148)
 OTHER
Bilateral Abducent Palsy in Leptospirosis- An Eye Opener to a Rare Neuro Ocular Manifestation: A Case Report.
Mahesh M Mbbs Md, Shivanagappa M Mbbs Md, Venkatesh CR Mbbs Md.
Iran J Med Sci. 2015;40(6):544-7.
Leptospirosis, a disease of great significance in tropical countries, presents commonly as a biphasic illness with acute febrile episode in the first phase followed by a brief afebrile period and then by the second phase of fever with or without jaundice and renal failure.
24557996
 MALE Adult
[Leptospirosis after refurbishment of old buildings].
Rugamer J, Kaaden R, Mohren W.
Dtsch Med Wochenschr. 2014;139(9):427-9.
Leptospirosis is a significant differential diagnosis in patients with fever, jaundice, headaches and myalgia.
25423604
 FEMALE
[Leptospirosis with necro-haemorrhagic cholecystitis in a Boxer puppy].
Steil D, Quandt A, Mayer-Scholl A, Sie JM, Lohr CV, Teifke JP.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2014;42(6):399-405.
The presumptive diagnosis of leptospirosis with acute renal failure, hepatic damage, and jaundice was confirmed by seroconversion (increased titre to 18202:8202800 in a non-vaccine serogroup 4 weeks after disease onset).
24623296
 MALE Middle Aged
Icterohaemorrhagic leptospirosis in patients with history of alcohol abuse - report of two cases.
Gancheva G, Karcheva M.
Turk J Gastroenterol. 2013;24(6):549-55.
The clinical spectrum of leptospirosis may be mild and self-limited or severe with jaundice, renal failure, and bleeding manifestations (icterohaemorrhagic leptospirosis, so called Weil's disease).
24623296
 MALE Middle Aged
Icterohaemorrhagic leptospirosis in patients with history of alcohol abuse - report of two cases.
Gancheva G, Karcheva M.
Turk J Gastroenterol. 2013;24(6):549-55.
The clinical spectrum of leptospirosis may be mild and self-limited or severe with jaundice, renal failure, and bleeding manifestations (icterohaemorrhagic leptospirosis, so called Weil's disease).
24095884
 MALE Adult
[Leptospirosis in Libreville (Gabon): four cases].
Magne MC, Ondounda M, Mbethe LG, Mounguengui D, Nzenze JR.
Med Sante Trop. 2013;23(3):347-50.
In tropical zones, the diagnosis of leptospirosis must be considered in all cases of febrile jaundice, especially when liver and kidney function are impaired.
22575986
 FEMALE Middle Aged
Leptospirosis: a re-emerging infection.
Sarkar J, Chopra A, Katageri B, Raj H, Goel A.
Asian Pac J Trop Med. 2012;5(6):500-2.
We present a fatal case of leptospirosis with acute liver failure, respiratory failure and jaundice and encephalopathy.
22361773
 FEMALE Adult
Prolonged jaundice attributed to super infection of hepatitis E virus in a case of resolving leptospirosis.
Singh MP, Majumdar M, Sharma A, Chawla Y, Ratho RK.
Indian J Med Microbiol. 2012;30(1):103-6.
Prolonged jaundice attributed to super infection of hepatitis E virus in a case of resolving leptospirosis.
21494219
 MALE Adult
Coupled plasma filtration-adsorption in Weil's syndrome: case report.
Moretti R, Scarrone S, Pizzi B, Bonato V, Vivaldi N.
Minerva Anestesiol. 2011;77(8):846-9.
Weil's syndrome is a form of leptospirosis characterized by jaundice, renal failure and hemorrhagic diathesis.
20440597
 FEMALE Young Adult
Leptospirosis as a cause of intrauterine fetal demise: short report of rare presentation.
Gainder S, Singla R, Dhaliwal L, Suri V.
Arch Gynecol Obstet. 2010;281(6):1061-3.
We present a rare severe leptospirosis in a patient who presented with fever, jaundice, coagulopathy and intrauterine fetal demise.
20981324
(2958626)
 OTHER
Leptospirosis: An Unusual Cause of ARDS.
Clavel M, Lheritier G, Weinbreck N, Guerlin A, Dugard A, Denes E, Vignon P.
Crit Care Res Pract. 2010;2010:408365.
Severe leptospirosis usually associates shock, jaundice, renal failure, and thrombocytopenia.
20358494
 MIXED_SAMPLE Middle Aged
[Leptospirosis (Weil's disease) in Augsburg].
Walter B, Wein B, Bittinger M, Messmann H.
Dtsch Med Wochenschr. 2010;135(14):675-8.
Leptospirosis is an important differential diagnosis in patients with recent onset of jaundice and acute renal failure.
20358494
 MIXED_SAMPLE Middle Aged
[Leptospirosis (Weil's disease) in Augsburg].
Walter B, Wein B, Bittinger M, Messmann H.
Dtsch Med Wochenschr. 2010;135(14):675-8.
The third patient showed a subsided leptospirosis, the jaundice having been due to a histologically confirmed drug-associated hepatitis.
17638021
 MALE
Severe acute renal failure in a child: a rare complication of anicteric leptospirosis.
da Silva PS, Lipinski RW, Magalhaes RP, Romero EC.
Pediatr Nephrol. 2007;22(11):1971-4.
This atypical case illustrates that, in the presence of fever, renal failure, rhabdomyolysis and thrombocytopenia, leptospirosis should be considered, even in the absence of jaundice or meningitis, especially if there is a history of contact with carrier animals.
17638021
 MALE
Severe acute renal failure in a child: a rare complication of anicteric leptospirosis.
da Silva PS, Lipinski RW, Magalhaes RP, Romero EC.
Pediatr Nephrol. 2007;22(11):1971-4.
Although the patient presented an atypical course without jaundice or meningeal involvement, early dialytic treatment was administered concomitant with empiric antibiotic therapy for leptospirosis.
16687602
 MALE Infant
Leptospirosis-induced meningitis and acute renal failure in a 19-month-old male child.
de Souza AL, Sztajnbok J, Marques SR, Seguro AC.
J Med Microbiol. 2006;55(Pt 6):795-7.
An unusual case of leptospirosis is described in a 19-month-old male child presenting with meningitis and acute renal failure without jaundice.