Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).

Anemia

A reduction in erythrocytes volume or hemoglobin concentration.


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PMID (PMCID)
28321090
 FEMALE Middle Aged
Splenic marginal zone lymphoma complicated by cold agglutinin disease.
Ochi K, Yokoyama K, Ohno N, Ota Y, Tojo A.
Rinsho Ketsueki. 2017;58(2):132-137.
A 48-year-old woman presented with severe anemia due to steroid-refractory cold agglutinin disease (CAD), and was referred to our hospital for management of progressive systemic illness and high fever.
28133289
 MALE Middle Aged
[Radical Operation Performed on a Gastric Cancer Patient with Cold Agglutinin Disease - A Case Report].
Wakasa Y, Wajima N, Akasaka H, Muroya T, Okano K, Yoshida E, Hakamada K.
Gan To Kagaku Ryoho. 2016;43(12):2262-2264.
The preoperative laboratory tests indicated anemia, hyperbilirubinemia, hemagglutinin reaction, and a markedly high cold agglutinin titer; thus, we diagnosed the patient with cold agglutinin disease(CAD).
25765801
 MALE
[Alleviated anemia by bendamustine in cold agglutinin disease associated with small lymphocytic lymphoma].
Kuno M, Inoue A, Aimoto M, Nakao T, Kameda K, Yoshida M, Kanashima H, Hirai M, Yamane T.
Rinsho Ketsueki. 2015;56(2):204-9.
[Alleviated anemia by bendamustine in cold agglutinin disease associated with small lymphocytic lymphoma].
1728870
 MALE Child
Cold agglutinin disease after chicken pox. An uncommon complication of a common disease.
Friedman HD, Dracker RA.
Am J Clin Pathol. 1992;97(1):92-6.
Reported here is the case of an 8-year-old boy who was found to have cold agglutinin disease and severe anemia several days after he contracted chicken pox.
1851246
 MALE Middle Aged
Peripheral neuropathy in cold agglutinin disease.
Thomas TD, Donofrio PD, Angelo J.
Muscle Nerve. 1991;14(4):331-4.
Cold agglutinin disease (CAD) characteristically presents as anemia and cold-induced rash.
576749
 MIXED_SAMPLE Middle Aged
Plasma exchange for cold agglutinin hemolytic anemia.
Taft EG, Propp RP, Sullivan SA.
Transfusion. 1977;17(2):173-6.
Two patients with advanced lymphoma, chronic cold agglutinin disease refractory to conventional therapy and severe, progressive anemia were treated with exchange plasma transfusion.