Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site.


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PMID (PMCID)
28698413
 FEMALE
[Aortic Stenosis Combined with Cold Agglutinin Disease].
Yu Z, Minakawa M, Aoki T, Kondo N, Daitoku K, Suzuki Y, Fukuda I.
Kyobu Geka. 2017;70(7):490-492.
Cardiac surgery on a patient with cold agglutinin disease is high risk for thromboembolism due to hypothermia perioperative.
21077318
 MALE Middle Aged
[Perioperative management of total laryngectomy for a patient with cold agglutinin disease].
Watanabe Y, Nikai T, Nosaka Y, Miyake K, Saito Y.
Masui. 2010;59(11):1435-7.
Cold agglutinin disease is possible to cause thromboembolism of various organs due to changes in red blood cells by exposure to low temperature.