Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).

Lymphadenopathy

Enlargment (swelling) of a lymph node.


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PMID (PMCID)
6807086
MALE Adult
B-cell neoplasms with homogeneous cold-reacting antibodies (cold agglutinins).
Crisp D, Pruzanski W.
Am J Med. 1982;72(6):915-22.
Patients wit chronic cold agglutinin disease had more hemolytic crises, bleeding and Raynaud's phenomena, and less frequently lymphadenopathy or hepatosplenomegaly.