Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).

Lymphoproliferative disorder



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PMID (PMCID)
30949369
 OTHER
Development of Multiple Myeloma of the IgA Type in a Patient with Cold Agglutinin Disease: Transformation or Coincidence?
Sefland O, Randen U, Berentsen S.
Case Rep Hematol. 2019;2019:1610632.
Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia and a distinct, clonal bone marrow lymphoproliferative disorder, characterized in most cases by a monoclonal IgM954 serum protein.
29991541
 FEMALE
Cold agglutinin-mediated autoimmune haemolytic anaemia associated with diffuse large B cell lymphoma.
Wongsaengsak S, Czader M, Suvannasankha A.
BMJ Case Rep. 2018;2018:.
While primary cold agglutinin disease is an idiopathic lymphoproliferative disorder, secondary cold agglutinin syndrome (CAS) complicates other diseases such as infections, autoimmune diseases and cancers, mostly low-grade lymphomas.
29991541
 FEMALE
Cold agglutinin-mediated autoimmune haemolytic anaemia associated with diffuse large B cell lymphoma.
Wongsaengsak S, Czader M, Suvannasankha A.
BMJ Case Rep. 2018;2018:.
While primary cold agglutinin disease is an idiopathic lymphoproliferative disorder, secondary cold agglutinin syndrome (CAS) complicates other diseases such as infections, autoimmune diseases and cancers, mostly low-grade lymphomas.
28487302
 FEMALE
Prophylactic use of eculizumab during surgery in chronic cold agglutinin disease.
Tjonnfjord E, Vengen OA, Berentsen S, Tjonnfjord GE.
BMJ Case Rep. 2017;2017:.
Primary chronic cold agglutinin disease (CAD) is an autoimmune haemolytic anaemia in which a specific bone marrow lymphoproliferative disorder causes production of cold agglutinins (CA).
12888170
 MIXED_SAMPLE Middle Aged
[Rituximab in cold agglutinin disease].
Camou F, Viallard JF, Pellegrin JL.
Rev Med Interne. 2003;24(8):501-4.
Cold agglutinin disease is a chronic auto-immune hemolytic anemia related to a lymphoproliferative disorder with a degenerative potential and no codified treatment.
8296193
 FEMALE Middle Aged
[Treatment of severe idiopathic cold-agglutinin diseases using interferon-alpha 2b].
Rordorf R, Barth A, Nydegger U, Tobler A.
Schweiz Med Wochenschr. 1994;124(1-2):56-61.
Based on in vitro evidence, primary cold agglutinin disease can be considered as a low grade malignant lymphoproliferative disorder in which interferon-alpha has been shown to be an effective therapeutic agent, at least in forms such as hairy cell leukemia.
3344409
 MIXED_SAMPLE
[Idiopathic cold agglutinin disease. Clinical aspects, therapy and course in 6 patients].
Budmiger H, Rhyner K, Siegenthaler-Zuber G, Bollinger A.
Schweiz Med Wochenschr. 1988;118(2):52-7.
One patient developed a lymphoproliferative disorder 11 years after diagnosis of idiopathic chronic cold agglutinin disease.