Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).

Gangrene

A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).


Total: 2

                       


(per page)
PMID (PMCID)
22513360
(3403954)
 OTHER
Cold autoimmune haemolytic anaemia secondary to Epstein Barr virus infection presenting with peripheral gangrene; case report.
Karunarathne S, Weerasinghe S, Govindapala D, Fernando H, Jayaratne B.
Thromb J. 2012;10(1):4.
Although acrocyanosis is commonly associated with cold agglutinin disease, gangrene is a rare complication.
8261977
 MALE Middle Aged
Paroxysmal cold haemoglobinuria coexisting with cold agglutinins in a patient with syphilis resulting in peripheral gangrene: a case report.
Patel M, Durao H, Govender Y.
East Afr Med J. 1993;70(8):526-7.
A 46-year-old male with syphilis, presented with an unusual combination of both paroxysmal cold haemoglobinuria and cold agglutinin disease, resulting in peripheral gangrene and requiring bilateral below knee amputations.